单词 | pharmacogenomics |
释义 | pharmacogenomicsphar·ma·co·ge·no·micsP5252800 (fär′mə-kō-jə-nō′mĭks)pharmacogenomics(ˌfɑːməkəʊdʒɪˈnɒmɪks)pharmacogenomicsphar·ma·co·ge·net·ics(far'mă-kō-jĕ-net'iks),pharmacogenomics(fär′mə-kō-jə-nō′mĭks)pharmacogenomicsThe formal study of inherited genetic variations that dictate different drug responses. Pharmacogenomics explores the ways such variations can be used to predict responses to investigational products and plays an increasingly important role in drug discovery.phar·ma·co·ge·net·ics, pharmacogenomics (fahr'mă-kō-jĕ-net'iks, -nō'miks)pharmacogenomicsThe recognition of the fact and significance of human genetic variability in relation to drug action and its application to medical treatment. Genetic variability affects drug absorption, distribution, metabolism and excretion. As a result, many drugs which work very well in some people work poorly in others. At present, the best doctors can do is to prescribe a drug and then wait and see how well the patient responds. Fuller knowledge of pharmacogenomics will, in the future, allow more reliable treatment and avoid expensive waste.pharmacogenomicsanalysis of the effects of GENOMICS on drug responses. This involves all the pharmacologically active genes, how they manifest their variations, how they interact to produce PHENOTYPES, and how these phenotypes affect drug responses. DNA MICROARRAYS/CHIPS should be useful in determining how genetic variation influences individual responses to a given drug or class of drugs. A major aim is to personalize drugs, by adapting them specifically to an individual's own genetic make-up, so that they will be fully efficacious with no side effects. |
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