单词 | tau protein |
释义 | tau proteintau proteintau proteintau protein[′tau̇ ‚prō‚tēn]tau proteintau proteintau proteintau proteinA major structural protein associated with the microtubules that form the cytoskeleton of nerve cells. An abnormal form with a shorter molecule is found in the helical filaments in senile neural plaques and in the insoluble neurofibrillary tangles of ALZHEIMER'S DISEASE. It is found in the cerebrospinal fluid of people with DEMENTIA but is present in higher concentration in Alzheimer's disease than in other forms of dementia. Abnormal tau protein binds strongly to the normal protein and the latter then become shortened by nerve cell proteolytic enzymes into the abnormal form. The latter is not split by these enzymes. It was reported in 2005 that when expression of a mutant tau gene in mice was turned off with doxycycline, lost memory was recovered to a surprising degree in spite of the presence of extensive neurofibrillary tangles. |
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