antisense

an·ti·sense

A0349150 (ăn′tē-sĕns′, ăn′tī-)adj. Of or relating to a nucleotide sequence that is complementary to a sequence of messenger RNA. When antisense DNA or RNA is added to a cell, it binds to a specific messenger RNA molecule and inactivates it.

an•ti•sense

(ˌæn tiˈsɛns, ˌæn taɪ-)
adj. of or pertaining to a gene that is derived from RNA or complementary DNA, is inserted in reverse orientation into a strand of DNA, and is used in genetic engineering to regulate genetic expression of a trait. [1985–90]

antisense

antisense,

DNA or RNA manipulated in a laboratory so that its components (nucleotides) form a complementary copy of normal, or "sense," messenger RNA (mRNA; see nucleic acidnucleic acid,
any of a group of organic substances found in the chromosomes of living cells and viruses that play a central role in the storage and replication of hereditary information and in the expression of this information through protein synthesis.
..... Click the link for more information. ). Antisense techniques are used to deactivate disease-causing or undesirable genes so that they cannot produce harmful or unwanted proteins. (Conventional drugs bind directly with disease-causing protein molecules, but their imperfect specificity may lead them to bind with other protein molecules, resulting in unwanted side effects. Antisense molecules are extremely specific.) In some applications of this technique, the antisense nucleic acid segment is inserted into an inactivated or nonvirulent virus, then introduced into the cell. The antisense segment pairs with the mRNA, preventing the synthesis of protein by the mRNA. Antisense has applications in agricultural biotechnology, where it has been used to deactivate the gene that causes softening in tomatoes, and in medicine, especially in cancer and antiviral therapy. See also gene therapygene therapy,
the use of genes and the techniques of genetic engineering in the treatment of a genetic disorder or chronic disease. There are many techniques of gene therapy, all of them still in experimental stages.
..... Click the link for more information. .

antisense

[¦an·tē′sens] (genetics) A strand of deoxyribonucleic acid having a sequence identical to messenger ribonucleic acid.

antisense

enUK

strand

[strand] a thread or fiber or a structure resembling one.antisense strand the strand of a double-stranded nucleic acid that is complementary to the strand" >sense strand; in DNA it is the template strand on which the mRNA is synthesized.sense strand the strand of a double-stranded nucleic acid that encodes the product; in DNA it is the strand that encodes the RNA, having thus the same base sequence except changing T for U in the RNA. See also strand" >antisense strand.

an·ti·sense DNA

the strand of DNA complementary to the one bearing the genetic message and from which it may be reconstructed; a DNA sequence complementary to a portion of mRNA; used as potential therapeutic agent to stop transcription or translation of pathogens or inappropriately expressed host gene.

antisense

(ăn′tē-sĕns′, ăn′tī-)adj. Of or relating to a nucleotide sequence that is complementary to a sequence of messenger RNA. When antisense DNA or RNA is added to a cell, it binds to a specific messenger RNA molecule and inactivates it.

gene therapy

Molecular medicine Treatment of disease by replacing, altering or supplementing the genetic structure of either germline–reproductive or somatic–nonreproductive cells a structure that is absent or abnormal and responsible for disease; any of a group of techniques in molecular biology, in which a gene of interest is manipulated, either by mutational inactivation–eg, the 'knock-out mouse', or by replacement, if it causes a particular disease; GT encompasses any therapy that specifically targets the core defect in inherited diseases, either by affecting somatic cells or germ line cells which are usually inserted into the host's genome; strategies for GT include 1. Introduction of a recombinant retrovirus with the missing gene, the promoter, and the gene regulator sequence in the 'package', and.2. Implantation of the colonies of cells producing the missing factor(s)–eg, α₁-antitrypsin deficiency with the missing enzyme introduced into 'carrier' fibroblasts Gene therapy strategies Antibody genes Interfere with cancer-related protein activity in tumor cells Antisense Block synthesis of proteins encoded by a defective gene in the host Chemoprotection Add proteins to cells that protect them from the toxic effect of chemotherapy Immunotherapy Enhance host defense against cancer Oncogene downregulation Turn off genes involved in uncontrolled growth and metastases of tumor cells Suicide gene/pro-drug therapy Insert proteins that metabolize normal drugs and ↑ their toxicity to proliferating–ie tumor cells Tumor suppressor genes Replace defective/deficient cancer-inhibiting genes .

an·ti·sense

(an'tē-sens) Pertaining to the strand of a double-stranded DNA or RNA molecule that is complementary to the sense strand.

单词	antisense
释义	antisense enUK an·ti·sense A0349150 (ăn′tē-sĕns′, ăn′tī-)adj. Of or relating to a nucleotide sequence that is complementary to a sequence of messenger RNA. When antisense DNA or RNA is added to a cell, it binds to a specific messenger RNA molecule and inactivates it. an•ti•sense (ˌæn tiˈsɛns, ˌæn taɪ-) adj. of or pertaining to a gene that is derived from RNA or complementary DNA, is inserted in reverse orientation into a strand of DNA, and is used in genetic engineering to regulate genetic expression of a trait. [1985–90] antisense enUK antisense, DNA or RNA manipulated in a laboratory so that its components (nucleotides) form a complementary copy of normal, or "sense," messenger RNA (mRNA; see nucleic acidnucleic acid, any of a group of organic substances found in the chromosomes of living cells and viruses that play a central role in the storage and replication of hereditary information and in the expression of this information through protein synthesis. ..... Click the link for more information. ). Antisense techniques are used to deactivate disease-causing or undesirable genes so that they cannot produce harmful or unwanted proteins. (Conventional drugs bind directly with disease-causing protein molecules, but their imperfect specificity may lead them to bind with other protein molecules, resulting in unwanted side effects. Antisense molecules are extremely specific.) In some applications of this technique, the antisense nucleic acid segment is inserted into an inactivated or nonvirulent virus, then introduced into the cell. The antisense segment pairs with the mRNA, preventing the synthesis of protein by the mRNA. Antisense has applications in agricultural biotechnology, where it has been used to deactivate the gene that causes softening in tomatoes, and in medicine, especially in cancer and antiviral therapy. See also gene therapygene therapy, the use of genes and the techniques of genetic engineering in the treatment of a genetic disorder or chronic disease. There are many techniques of gene therapy, all of them still in experimental stages. ..... Click the link for more information. . antisense [¦an·tē′sens] (genetics) A strand of deoxyribonucleic acid having a sequence identical to messenger ribonucleic acid. antisense enUK strand [strand] a thread or fiber or a structure resembling one.antisense strand the strand of a double-stranded nucleic acid that is complementary to the strand" >sense strand; in DNA it is the template strand on which the mRNA is synthesized.sense strand the strand of a double-stranded nucleic acid that encodes the product; in DNA it is the strand that encodes the RNA, having thus the same base sequence except changing T for U in the RNA. See also strand" >antisense strand. an·ti·sense DNA the strand of DNA complementary to the one bearing the genetic message and from which it may be reconstructed; a DNA sequence complementary to a portion of mRNA; used as potential therapeutic agent to stop transcription or translation of pathogens or inappropriately expressed host gene. antisense (ăn′tē-sĕns′, ăn′tī-)adj. Of or relating to a nucleotide sequence that is complementary to a sequence of messenger RNA. When antisense DNA or RNA is added to a cell, it binds to a specific messenger RNA molecule and inactivates it. gene therapy Molecular medicine Treatment of disease by replacing, altering or supplementing the genetic structure of either germline–reproductive or somatic–nonreproductive cells a structure that is absent or abnormal and responsible for disease; any of a group of techniques in molecular biology, in which a gene of interest is manipulated, either by mutational inactivation–eg, the 'knock-out mouse', or by replacement, if it causes a particular disease; GT encompasses any therapy that specifically targets the core defect in inherited diseases, either by affecting somatic cells or germ line cells which are usually inserted into the host's genome; strategies for GT include 1. Introduction of a recombinant retrovirus with the missing gene, the promoter, and the gene regulator sequence in the 'package', and.2. Implantation of the colonies of cells producing the missing factor(s)–eg, α₁-antitrypsin deficiency with the missing enzyme introduced into 'carrier' fibroblasts Gene therapy strategies Antibody genes Interfere with cancer-related protein activity in tumor cells Antisense Block synthesis of proteins encoded by a defective gene in the host Chemoprotection Add proteins to cells that protect them from the toxic effect of chemotherapy Immunotherapy Enhance host defense against cancer Oncogene downregulation Turn off genes involved in uncontrolled growth and metastases of tumor cells Suicide gene/pro-drug therapy Insert proteins that metabolize normal drugs and ↑ their toxicity to proliferating–ie tumor cells Tumor suppressor genes Replace defective/deficient cancer-inhibiting genes . an·ti·sense (an'tē-sens) Pertaining to the strand of a double-stranded DNA or RNA molecule that is complementary to the sense strand. ThesaurusSeestrand
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