ubenimex
ubenimex
Alternative oncologyA competitive protease-inhibiting peptide isolated from the supernatant broth of cultured Streptomyces olivoreticuli that inhibits aminopeptidases B and N and leukotriene A4 hydrolase. Ubenimex stimulates the immune system, activates macrophages, increases production and secretion of IL-1 and IL-2, and stimulates T cells and haematopoiesis. It is in clinical trials for acute myeloid leukaemia and may be effective in treating various cancers, including Hodgkin lymphoma, leukaemia, melanoma, and cancers of the bladder, oesophagus, head and neck, lung and stomach.