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somatomedin
so·mat·o·me·din S0555550 (sō-măt′ə-mēd′n, sō′mə-tə-)n. See insulin-like growth factor.
[Perhaps somato(tropin) + (inter)med(iary) + -in.]somatomedin (ˌsəʊmətəˈmiːdɪn) n (Biochemistry) a protein hormone that promotes tissue growth under the influence of growth hormone[C20: from somato- + Latin medius middle + -in]so•mat•o•me•din (səˌmæt əˈmid n)
n. any of various liver hormones that enhance the activity of a variety of other hormones, as somatotropin. [1970–75; somato- + -med-, as in intermediary] somatomedin
somatomedin[sə‚mad·ə′med·ən] (biochemistry) A growth factor similar to insulin that may be produced by a variety of cell types. Also known as insulin-like growth factor. somatomedin
somatomedin [so″mah-to-me´din] any of a group of peptides found in the liver and in other tissues which mediate the effect of growth hormone (somatotropin) on cartilage; they are responsible for uptake of sulfate and increased synthesis of collagen and other proteins by cartilage. Somatomedins also have insulinlike biologic actions and increase RNA synthesis and promote DNA synthesis.so·ma·to·me·din (sō'mă-tō-mē'din), One of several peptides; somatomedin peptide (MW about 4,000), also called insulinlike growth factor II, is synthesized in the liver and probably in the kidney; it is capable of stimulating certain anabolic processes in bone and cartilage, such as synthesis of DNA, RNA, and protein (including chondromucoprotein), and the sulfation of mucopolysaccharides; secretion and biologic activity of somatomedin is known to depend on somatotropin.
See also: insulinlike growth factor. [somato, tropin + mediator + -in] somatomedin (sō-măt′ə-mēd′n, sō′mə-tə-)n. See insulin-like growth factor.somatomedin Any of a group of hormones that mediate the effects of growth hormone (formally, somatopropin):
(1) Insulin-like growth factor-I (somatomedin C);
(2) Insulin-like growth factor-II (somatomedin A);
(3) Vitronectin (somatomedin B).so·ma·to·me·din (sō'mă-tō-mē'din) A peptide synthesized in the liver, and probably also in the kidney, capable of stimulating certain anabolic processes in bone and cartilage, such as synthesis of DNA, RNA, and protein, and the sulfation of mucopolysaccharides; secretion or biologic activity of somatomedin is known to depend on somatotropin. [somato, tropin + mediator + -in]so·ma·to·me·din (sō'mă-tō-mē'din) One of several peptides; also called insulinlike growth factor II, is synthesized in the liver and probably kidney. [somato, tropin + mediator + -in] |