phenylalanine 4-monooxygenase

phen·yl·al·a·nine 4-mon·o·ox·y·gen·ase

an enzyme that catalyzes oxidation of l-phenylalanine to l-tyrosine with O2 and tetrahydrobiopterin (the latter forming the dihydro derivative) which is, in turn, reduced by NADPH and dihydropteridine reductase to the active form); a deficiency of either phenylalanine 4-monooxyenase or dihydropteridine reductase will result in phenylketonuria. Synonym(s): phenylalanine 4-hydroxylase

phen·yl·al·a·nine 4-mon·o·ox·y·gen·ase

(fen'il-al'ă-nēn mon'ō-ok'si-jĕn-ās) An enzyme that catalyzes the oxidation of l-phenylalanine to l-tyrosine; a deficiency results in phenylketonuria.
Synonym(s): phenylalaninase.