SAPHO syndrome

Synovitis Acne Palmoplantar Pustulosis Hyperostosis Osteitis. A rare association of severe acne and arthralgia/arthritis, which is more common in men.

Clinical findings
The acne affects the face, upper back and trunk, and is accompanied by fever and weight loss. The pain usually affects the hips, knees, shoulders, and occasionally other sites. The arthritis usually affects the lower limbs; it may be acute and polyarticular.

Lab
Increased erythrocyte sedimentation rate (ESR), increased leukocytes, decreased serum complement, negative ANA, negative rheumatoid factors, presence of circulating immune complexes.

Management
NSAIDs for pain, arthritis; corticosteroids for severe pain and recalcitrant acne.

SAPHO syndrome

A syndrome characterized by synovitis, acne, pustulosis, hyperostosis, osteitis

单词	sapho syndrome
释义	SAPHO syndrome SAPHO syndrome Synovitis Acne Palmoplantar Pustulosis Hyperostosis Osteitis. A rare association of severe acne and arthralgia/arthritis, which is more common in men. Clinical findings The acne affects the face, upper back and trunk, and is accompanied by fever and weight loss. The pain usually affects the hips, knees, shoulders, and occasionally other sites. The arthritis usually affects the lower limbs; it may be acute and polyarticular. Lab Increased erythrocyte sedimentation rate (ESR), increased leukocytes, decreased serum complement, negative ANA, negative rheumatoid factors, presence of circulating immune complexes. Management NSAIDs for pain, arthritis; corticosteroids for severe pain and recalcitrant acne. SAPHO syndrome A syndrome characterized by synovitis, acne, pustulosis, hyperostosis, osteitis
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