| Acronym | Definition |
|---|
| TLSM➣The Living Savior Ministries (Justin, TX) |
| TLSM➣Thymic Lymphoma Susceptible Mouse |
| TLSM➣Tramo Libre Sin Muerte (Spanish: No-Kill Free Section; fishing designation; various locations) |
| TLSM➣Thinking-Logic-Story-Media (business communication) |
| TLSM➣Transport Layer Security Model |
| TLSM➣Threshold-Linear Sire-Maternal Grandsire (animal science) |
| TLSM➣Trauma Life Support in Motorsport |