STK24

A gene on chromosome 13q31.2-q32.3 that encodes a serine/threonine-protein kinase which acts on serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. STK24 mediates oxidative-stress-induced cell death by phosphorylating JNK1-JNK2 (MAPK8 and MAPK9) and p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. It regulates cellular migration by altering PTPN12 activity and PXN phosphorylation, and it may be a key regulator of axon regeneration in the optic and radial nerves.

单词	stk24
释义	STK24 STK24 A gene on chromosome 13q31.2-q32.3 that encodes a serine/threonine-protein kinase which acts on serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. STK24 mediates oxidative-stress-induced cell death by phosphorylating JNK1-JNK2 (MAPK8 and MAPK9) and p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. It regulates cellular migration by altering PTPN12 activity and PXN phosphorylation, and it may be a key regulator of axon regeneration in the optic and radial nerves.
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