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Shwartzman phenomenon
Shwartzman phenomenon[′shwȯrts·mənfə‚näm·ə‚nän] (immunology) A type of local tissue reactivity in the skin in which a preparatory injection of the endotoxin is followed by an intravenous injection of the same or another endotoxin 24 hours later, producing immediate neutropenia and thrombopenia with the development of leukocyte-platelet thrombi with subsequent hemorrhage. Shwartzman phenomenon
Shwartzman phenomenon [shwarts´man] a local tissue reaction characterized by hemorrhagic necrosis due to an antigen-antibody reaction to certain bacterial substances. Its occurrence in humans is largely theoretical.Shwartz·man phe·nom·e·non (shwarts'măn), that a rabbit injected intradermally with a small quantity of lipopolysaccharide (endotoxin) followed by a second intravenous injection 24 hours later will develop a hemorrhagic and necrotic lesion at the site of the first injection.
See also: generalized Shwartzman phenomenon. Synonym(s): Shwartzman reactionShwartz·man phe·nom·e·non (shwarts'mahn fĕ-nom'ĕ-non) A rabbit injected intradermally with a small quantity of lipopolysaccharide (endotoxin) followed by a second intravenous injection 24 hours later develops a hemorrhagic and necrotic lesion at the site of the first injection.
See also: generalized Shwartzman phenomenonShwartzman, Gregory, Russian bacteriologist in U.S., 1896-1965. generalized Shwartzman phenomenon - death occurs in an animal that has been injected with a primary injection of endotoxin-containing filtrate and secondary injection given intravenously 24 hours apart. Synonym(s): Sanarelli phenomenon; Sanarelli-Shwartzman phenomenonSanarelli-Shwartzman phenomenon - Synonym(s): generalized Shwartzman phenomenonShwartzman phenomenon - a rabbit injected intradermally with a small quantity of endotoxin followed by a second intravenous injection 24 hours later will develop a hemorrhagic and necrotic lesion at the site of the first injection. Synonym(s): Shwartzman reactionShwartzman reaction - Synonym(s): Shwartzman phenomenon |