pure autonomic failure


pure autonomic failure

a degenerative, sporadic neurologic disorder of adult onset, manifested principally as orthostatic hypotension and syncope, with no neurologic defects other than autonomic nervous system dysfunction evident; probably caused by selective degeneration of neurons in the sympathetic ganglia, with denervation of smooth muscle vasculature and the adrenal glands. Synonym(s): Bradbury-Eggleston syndrome

pure autonomic failure

Neurology A sporadic, idiopathic cause of persistent orthostatic hypotensio in and other manifestations of autonomic failure, unaccompanied by other neurologic features

pure au·to·nom·ic fail·ure

(pyūr aw'tō-nom'ik fāl'yŭr) A degenerative, sporadic neurologic disorder of adult onset, manifested principally as orthostatic hypotension and syncope, with no neurologic defects other than autonomic nervous system dysfunction evident; probably caused by selective degeneration of neurons in the sympathetic ganglia, with denervation of smooth muscle vasculature and the suprarenal glands.
Synonym(s): Bradbury-Eggleston syndrome.