AZT

A0562500 (ā′zē-tē′)n. An antiviral drug, C₁₀H₁₃N₅O₄, that is a nucleoside reverse transcriptase inhibitor and is used in combination with other drugs for the treatment of HIV infection. Also called zidovudine.

[az(ido)t(hymidine).]

AZT

abbreviation for (Pharmacology) azidothymidine. Also called: zidovudine

AZT

Trademark. azidothymidine: an antiviral drug used in the treatment of AIDS. Compare zidovudine.

Thesaurus

Noun

AZT - an antiviral drug (trade name Retrovir) used in the treatment of AIDS; adverse side effects include liver damage and suppression of the bone marrowRetrovir, ZDV, zidovudineNRTI, nucleoside reverse transcriptase inhibitor - an antiviral drug used against HIV; is incorporated into the DNA of the virus and stops the building process; results in incomplete DNA that cannot create a new virus; often used in combination with other drugs

Translations

AZT

zidovudine

(zīdō`vyo͞odēn'), drug used to treat patients infected with the human immunodeficiency virus (HIVHIV,
human immunodeficiency virus, either of two closely related retroviruses that invade T-helper lymphocytes and are responsible for AIDS. There are two types of HIV: HIV-1 and HIV-2. HIV-1 is responsible for the vast majority of AIDS in the United States.
..... Click the link for more information. ), which causes AIDSAIDS
or acquired immunodeficiency syndrome,
fatal disease caused by a rapidly mutating retrovirus that attacks the immune system and leaves the victim vulnerable to infections, malignancies, and neurological disorders. It was first recognized as a disease in 1981.
..... Click the link for more information. ; also called azidothymidine. Originally developed in 1964 as an anticancer drug, AZT was never approved for that purpose. In 1984, Burroughs-Wellcome Company, which owned the rights to the drug, reexamined it as part of a search for any antiviral drugantiviral drug,
any of several drugs used to treat viral infections. The drugs act by interfering with a virus's ability to enter a host cell and replicate itself with the host cell's DNA.
..... Click the link for more information. that might be effective against the AIDS virus. It was approved by the FDA in 20 months, rather than the usual 8 to 10 years, in part for humanitarian reasons; thousands of people were dying of AIDS, no other treatment was forthcoming, and AIDS activists were lobbying heavily for approval.

AZT affects HIV's ability to reproduce by inhibiting the transcription of RNA to DNA. Although AZT can be helpful in the short term by promoting weight gain, decreasing the number of opportunistic infections, and improving T4 (CD4) lymphocyte counts (see immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
..... Click the link for more information. ), some researcher believe studies of its effectiveness to be flawed and regard the drug as too toxic for long-term use. There is also a question of whether it is helpful in HIV-positive, asymptomatic people. AZT does not cure or prevent AIDS, nor does it keep one from transmitting the virus to others, although some studies show that it does lessen the possibility that an HIV-infected mother will transmit the virus to her fetus.

Adverse effects include bone marrow depression, headache, nausea, muscle pain, and a reduction in the number of certain white blood cells. The risk of side effects increases when certain other drugs, including acetaminophenacetaminophen
, an analgesic and fever-reducing medicine. It is an active ingredient in many over-the-counter medicines, including Tylenol and Midol. Introduced in the early 1900s, acetaminophen is a coal tar derivative that acts by interfering with the synthesis of
..... Click the link for more information. , are taken at the same time.

AZT

zidovudine

[zi-do´vu-dēn] a analogue" >nucleoside analogue to thymidine, used as an antiretroviral agent in treatment of patients with virus" >human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS); administered orally or intravenously. It was the first agent approved for such use.

AZT

Abbreviation for azidothymidine. See: zidovudine.

AZT

(ā′zē-tē′)n. An antiviral drug, C₁₀H₁₃N₅O₄, that is a nucleoside reverse transcriptase inhibitor and is used in combination with other drugs for the treatment of HIV infection. Also called zidovudine.

AZT

A nucleoside analogue used with other anti-HIV agents to manage AIDS and HIV infection.

Adverse effects
Long-term AZT use is associated with muscle loss, nausea, anaemia, myelosuppression, oral ulcers, bone marrow damage and headache.

AZT

3'-azido-3'-deoxythimidine, zidovudine, Retrovir AIDS A nucleoside analogue, used with other anti-HIV agents to manage AIDS and HIV infection Adverse effects Long-term AZT use is associated with muscle loss, nausea, anemia, myelosuppression, oral ulcers, BM damage, headache. See AIDS, HAART.

AZT

Abbreviation for azidothymidine.
See: zidovudine

AZT

Abbrev. for azidothymidine or Zidovudine. A drug used in attempts to control AIDS. The drug is toxic but does seem to be able to prolong life. A short course of AZT has been shown to be capable of halving the incidence of transmission of HIV from mother to baby. AZT is now commonly used in combination with other anti-HIV drugs especially protease inhibitors.

AZT

Abbreviation for azidothymidine.
See: zidovudine.

Acronym

Definition

AZT➣Azido-Thymidine (AIDS drug)

AZT➣Zidovudine (antiretroviral drug)

AZT➣Allianz Zentrum für Technik GmbH (German automotive safety standards)

AZT➣Automobilklub Ziemi Tyskiej (Polish motor sports series)

AZT➣Aschheim-Zondek Test

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Synonyms for AZT

noun an antiviral drug (trade name Retrovir) used in the treatment of AIDS

Synonyms

Related Words