PJs
PJs
or PJ's or pj's P0341150 (pē′jāz′)PJs
(piːˈdʒeɪz) orpj's
pa•ja•mas
(pəˈdʒɑ məz, -ˈdʒæm əz)n. (used with a pl. v.)
单词 | pjs | |||||||||||||
释义 | PJsPJsor PJ's or pj's P0341150 (pē′jāz′)PJs(piːˈdʒeɪz) orpj'spa•ja•mas(pəˈdʒɑ məz, -ˈdʒæm əz)n. (used with a pl. v.) PJsPJsPJsPJSSTK11A gene on chromosome 19p13.3 that encodes a ubiquitously expressed serine/threonine-protein kinase which controls the activity of AMP-activated protein kinase (AMPK) family members, playing a role in various cellular processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. STK11 acts by phosphorylating the T-loop of AMPK family proteins, upregulating their activity.Molecular pathology Defects in STK11 are a cause of Peutz-Jeghers syndrome; it has been linked to testicular germ cell tumours and sporadically to non-small cell carcinomas of the lung. Defects in STK11 also promote carcinogenesis, including lung cancer progression and metastasis, and confers in lung adenocarcinoma the ability to trans-differentiate into squamous cell carcinoma. PJSPJS
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