plakoglobin
plakoglobin
A protein encoded by JUP on chromosome 17q21, which is the core molecule in the submembranous plaques of desmosomes and intermediate junctions, and forms complexes with cadherins. It is a member of the catenin protein family as it contains a so-called armadillo repeat.Interactions
Beta-catenin, MUC1, CDH1, CDH2, CDH3, E-cadherin, desmoglein 2, desmoplakin.
Abnormal in
JUP mutations are associated with arrhythmogenic right ventricular cardiomyopathy and Naxos syndrome.