pyoderma gangrenosum

Note: This page may contain terms or definitions that are offensive or inappropriate for some readers.

pyoderma

[pi″o-der´mah] any purulent skin disease.pyoderma gangreno´sum a rapidly evolving cutaneous ulcer or ulcers, with undermining of the border. Once regarded as a complication peculiar to ulcerative colitis, it is now known to occur in other wasting diseases.

py·o·der·ma gan·gre·no·'sum

a chronic, noninfective eruption of spreading, undermined ulcers showing central healing, with diffuse dermal neutrophil infiltration; often associated with ulcerative colitis.

pyoderma gangrenosum

An uncommon idiopathic condition which begins as papules and pustules in the follicles, followed by a rapidly expanding necrotic ulcer measuring 3 to 30 cm and rimmed by violaceous erythema. At least half of patients have associated systemic disease, including infection, malignancy, vasculitis, collagen vascular disease, diabetes, or trauma; it may have an autoimmune component.
Clinical findings
An initial bite-like lesion, pain, arthralgias and malaise; the classic ulcers occur on the legs; a superficial variant—atypical PG—tends to occur on the hands; involvement of other organ systems manifests as sterile neutrophilic abscesses in the lungs, heart, CNS, GI tract, eyes, liver, spleen, bone, and lymph nodes.

Associated conditions
IBD—either ulcerative colitis or Crohn’s disease, asymmetric polyarthritis, hematologic disorders (e.g., leukaemia or preleukaemia), predominantly myelocytic, monoclonal gammopathies, especially IgA gammopathy. Less common associations include arthritides (e.g., psoriatic arthritis, osteoarthritis, or spondyloarthropathy), liver disease (e.g., hepatitis and primary biliary cirrhosis), myeloma (especially IgA type) and immunologic diseases (e.g., SLE, Sjögren syndrome).

DiffDx
Ulcers due to infection, malignancy, stasis, vasculitis, necrotising fasciitis, acute febrile neutrophilic dermatosis, aphthous stomatitis, atrophie blanche, Behçet disease, chancroid, Churg-Strauss syndrome (allergic granulomatosis), ecthyma gangrenosum, herpes simplex, hypersensitivity vasculitis (leukocytoclastic vasculitis), impetigo, insect bites, sporotrichosis, squamous cell carcinoma, venous insufficiency, verrucous carcinoma, Wegener’s granulomatosis.

Management
Anti-inflammatories (e.g., corticosteroids), immunosuppressants.

pyoderma gangrenosum

Dermatology A rare idiopathic condition characterized by skin ulceration; at least 50% of Pts have associated systemic disease, including infection, malignancy, vasculitis, collagen vascular diseases, DM, trauma Clinical An initial bite-like lesion, pain, arthralgias and malaise; the classic ulcers occur on the legs; a superficial variant, atypical PG, tends to occur on the hands; involvement of other organ systems manifests as sterile neutrophilic abscesses in the lungs, heart, CNS, GI tract, eyes, liver, spleen, bone, and lymph nodes Associated conditions IBD–either ulcerative colitis or Crohn's disease, a symmetric polyarthritis, hematologic disorders–eg, leukemia or preleukemia, predominantly myelocytic, monoclonal gammopathies, especially IgA gammopathy; less common associations include arthritides–eg, psoriatic arthritis, osteoarthritis, or spondyloarthropathy; liver disease–eg, hepatitis and primary biliary cirrhosis; myeloma–especially IgA type and immunologic diseases–eg, SLE, Sjögren's DiffDx Acute febrile neutrophilic dermatosis, aphthous stomatitis, atrophie blanche, Behçet disease, chancroid, Churg-Strauss syndrome–allergic granulomatosis, ecthyma, ecthyma gangrenosum, herpes simplex, hypersensitivity vasculitis–leukocytoclastic vasculitis, impetigo, insect bites, sporotrichosis, SCC, venous insufficiency, verrucous carcinoma, Wegener's granulomatosis Management Anti-inflammatories–eg, corticosteroids, immunosuppressants

py·o·der·ma gan·gre·no·sum

(pī'ō-dĕr'mă gang-grĕ-nō'sŭm) A chronic, noninfective eruption of spreading, undermined ulcers showing central healing, with diffuse dermal neutrophil infiltration; often associated with ulcerative colitis.

PYODERMA GANGRENOSUM OF THE LOWER LEG

pyoderma gangrenosum

A rare, ulcerating skin disease in which the skin is infiltrated by neutrophils. It is often found in people with other underlying illnesses, such as inflammatory bowel disease, rheumatoid arthritis, or some hematological malignancies. See: illustrationSee also: pyoderma

pyoderma gangrenosum

A rare disease featuring areas of gangrene of the skin, mainly affecting the legs. In spite of the name, the condition is not of infective origin. It occurs in a small percentage of people with ULCERATIVE COLITIS.

单词	pyoderma gangrenosum
释义	pyoderma gangrenosum Note: This page may contain terms or definitions that are offensive or inappropriate for some readers.Translations EncyclopediaSeePyoderma pyoderma gangrenosum Note: This page may contain terms or definitions that are offensive or inappropriate for some readers. pyoderma [pi″o-der´mah] any purulent skin disease.pyoderma gangreno´sum a rapidly evolving cutaneous ulcer or ulcers, with undermining of the border. Once regarded as a complication peculiar to ulcerative colitis, it is now known to occur in other wasting diseases. py·o·der·ma gan·gre·no·'sum a chronic, noninfective eruption of spreading, undermined ulcers showing central healing, with diffuse dermal neutrophil infiltration; often associated with ulcerative colitis. pyoderma gangrenosum An uncommon idiopathic condition which begins as papules and pustules in the follicles, followed by a rapidly expanding necrotic ulcer measuring 3 to 30 cm and rimmed by violaceous erythema. At least half of patients have associated systemic disease, including infection, malignancy, vasculitis, collagen vascular disease, diabetes, or trauma; it may have an autoimmune component. Clinical findings An initial bite-like lesion, pain, arthralgias and malaise; the classic ulcers occur on the legs; a superficial variant—atypical PG—tends to occur on the hands; involvement of other organ systems manifests as sterile neutrophilic abscesses in the lungs, heart, CNS, GI tract, eyes, liver, spleen, bone, and lymph nodes. Associated conditions IBD—either ulcerative colitis or Crohn’s disease, asymmetric polyarthritis, hematologic disorders (e.g., leukaemia or preleukaemia), predominantly myelocytic, monoclonal gammopathies, especially IgA gammopathy. Less common associations include arthritides (e.g., psoriatic arthritis, osteoarthritis, or spondyloarthropathy), liver disease (e.g., hepatitis and primary biliary cirrhosis), myeloma (especially IgA type) and immunologic diseases (e.g., SLE, Sjögren syndrome). DiffDx Ulcers due to infection, malignancy, stasis, vasculitis, necrotising fasciitis, acute febrile neutrophilic dermatosis, aphthous stomatitis, atrophie blanche, Behçet disease, chancroid, Churg-Strauss syndrome (allergic granulomatosis), ecthyma gangrenosum, herpes simplex, hypersensitivity vasculitis (leukocytoclastic vasculitis), impetigo, insect bites, sporotrichosis, squamous cell carcinoma, venous insufficiency, verrucous carcinoma, Wegener’s granulomatosis. Management Anti-inflammatories (e.g., corticosteroids), immunosuppressants. pyoderma gangrenosum Dermatology A rare idiopathic condition characterized by skin ulceration; at least 50% of Pts have associated systemic disease, including infection, malignancy, vasculitis, collagen vascular diseases, DM, trauma Clinical An initial bite-like lesion, pain, arthralgias and malaise; the classic ulcers occur on the legs; a superficial variant, atypical PG, tends to occur on the hands; involvement of other organ systems manifests as sterile neutrophilic abscesses in the lungs, heart, CNS, GI tract, eyes, liver, spleen, bone, and lymph nodes Associated conditions IBD–either ulcerative colitis or Crohn's disease, a symmetric polyarthritis, hematologic disorders–eg, leukemia or preleukemia, predominantly myelocytic, monoclonal gammopathies, especially IgA gammopathy; less common associations include arthritides–eg, psoriatic arthritis, osteoarthritis, or spondyloarthropathy; liver disease–eg, hepatitis and primary biliary cirrhosis; myeloma–especially IgA type and immunologic diseases–eg, SLE, Sjögren's DiffDx Acute febrile neutrophilic dermatosis, aphthous stomatitis, atrophie blanche, Behçet disease, chancroid, Churg-Strauss syndrome–allergic granulomatosis, ecthyma, ecthyma gangrenosum, herpes simplex, hypersensitivity vasculitis–leukocytoclastic vasculitis, impetigo, insect bites, sporotrichosis, SCC, venous insufficiency, verrucous carcinoma, Wegener's granulomatosis Management Anti-inflammatories–eg, corticosteroids, immunosuppressants py·o·der·ma gan·gre·no·sum (pī'ō-dĕr'mă gang-grĕ-nō'sŭm) A chronic, noninfective eruption of spreading, undermined ulcers showing central healing, with diffuse dermal neutrophil infiltration; often associated with ulcerative colitis. PYODERMA GANGRENOSUM OF THE LOWER LEG pyoderma gangrenosum A rare, ulcerating skin disease in which the skin is infiltrated by neutrophils. It is often found in people with other underlying illnesses, such as inflammatory bowel disease, rheumatoid arthritis, or some hematological malignancies. See: illustrationSee also: pyoderma pyoderma gangrenosum A rare disease featuring areas of gangrene of the skin, mainly affecting the legs. In spite of the name, the condition is not of infective origin. It occurs in a small percentage of people with ULCERATIVE COLITIS. AcronymsSeePG
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