| Acronym | Definition |
|---|
| SCIO➣Subsystem Computer Input Output |
| SCIO➣Spinal Cord Injury Ontario (advocacy; Ontario, Canada) |
| SCIO➣State Chief Information Officer (various states) |
| SCIO➣Scottish Charitable Incorporated Organisation (legal designation; Scotland, UK) |
| SCIO➣Sudan Catholic Information Office (Nairobi, Kenya) |
| SCIO➣Staffordshire & Stoke-on-Trent Consortium of Infrastructure Organisations (UK) |
| SCIO➣State Council Informatization Office (China) |
| SCIO➣Staff Counterintelligence Officer |