bicuspid aortic valve


valve

 [valv] a membranous fold in a canal or passage that prevents backward flow of material passing through it.aortic valve a valve" >semilunar valve that separates the left ventricle and the aorta; it opens with end diastole, causing the second heart sound.atrioventricular v's the valves" >cardiac valves between the right atrium and right ventricle (tricuspid valve) and the left atrium and left ventricle (mitral valve).bicuspid valve mitral valve.bicuspid aortic valve a congenital anomaly of the aortic valve, caused by incomplete separation of two of the three cusps; it is generally asymptomatic early in life but is predisposed to calcification and stenosis later on.Braschi valve a one-way valve put into the inspiratory limb of a ventilator circuit in order to measure the pressure" >intrinsic positive end-expiratory pressure.cardiac v's valves that control flow of blood through and from the heart.coronary valve a valve at the entrance of the coronary sinus into the right atrium.flail mitral valve a valve" >mitral valve having a cusp that has lost its normal support (as in ruptured chordae tendineae) and flutters in the blood stream.heart v's cardiac valves.Heimlich valve a small one-way valve used for chest drainage, emptying into a flexible collection device; the valve prevents return of gases or fluids into the pleural space. The Heimlich valve is less than 13 cm (5 inches) long and facilitates patient ambulation; it can be used in many patients instead of a traditional water seal drainage system.ileocecal valve (ileocolic valve) the valve guarding the opening between the ileum and cecum.mitral valve the valve" >cardiac valve between the left atrium and left ventricle, usually having two cusps (anterior and posterior). Called also bicuspid valve.Valves of the heart. The right heart pumps the venous blood into the lungs. The oxygenated blood returns from the lungs into the left atrium and is propelled by the left ventricle into the aorta. The insets show closed valves: the tricuspid valve has three leaflets, whereas the mitral valve has two leaflets. The aortic and pulmonary artery valves have three leaflets and resemble one another except for the fact that the coronary arteries originate from behind the cusps in the aorta. From Damjanov, 1996.posterior urethral valve any of various types of congenital folds across the proximal part of the male urethra near the colliculus" >seminal colliculus, the most common cause of urethral obstruction in male infants.pulmonary valve (pulmonic valve) the pocketlike valve" >cardiac valve that protects the orifice between the right ventricle and the pulmonary artery.pyloric valve a prominent fold of mucous membrane at the pyloric orifice of the stomach.semilunar v's the valves" >cardiac valves that have cusps" >semilunar cusps; see aortic valve and pulmonary valve.thebesian valve coronary valve.tricuspid valve the valve" >cardiac valve guarding the opening between the right atrium and right ventricle.valve of vein (venous v's) any of the small cusps or folds found in the tunica intima of many veins, serving to prevent backflow of blood.

fa·mil·i·al a·or·tic ec·ta·si·a syn·drome

the concurrence as an autosomal dominant trait of bicuspid aortic valve often with premature calcification, ectasia, and dissection of the aorta and, rarely, coarctation of the aorta. Superficially resembles the Marfan syndrome. Synonym(s): familial aortic ectasia

bicuspid aortic valve

A congenital heart defect in which the aortic annulus has 2 instead of 3 semilunar valves, a finding in up to 3% of the population. The male:female ratio is 4:1; 20% of those with a bicuspid aortic valves have other cardiac defects—e.g., patent ductus arteriosus or aortic coarctation. The valve is subjected to abnormal hemodynamic stress, leading to leaflet thickening, calcification and aortic stenosis; in absence of other cardiac defects, bicuspid aortic valves are not associated with increased mortality.
Molecular pathology
BAVs are associated with an increase in aneurysms of the ascending aorta, which is attributed to an alteration of the extracellular matrix and an increase in the ratio of matrix metalloproteinase (MMP) 2 to tissue inhibitor of metalloproteinase (TIMP)1.

bicuspid aortic valve

Cardiology A congenital heart defect in which the aortic annulus has 2 instead of 3 semilunar valves, seen in 3% of the population; ♂:♀, 4:1; 20% of those with a BAV have other cardiovascular disease–eg, PDA or aortic coarctation; the valve is subjected to abnormal hemodynamic stress, leading to leaflet thickening, calcification and aortic stenosis. See Aortic stenosis.