| 释义 |
streptozocin
strep·to·zo·cin S5873850 (strĕp′tə-zō′sĭn)n. See streptozotocin.streptozocin
streptozocin [strep″to-zo´sin] an antitumor antibiotic derived from Streptomyces achromogenes, now produced synthetically. It contains a nitrosourea group linked to a methyl group and a glucosamine moiety and acts as an alkylating agent to inhibit DNA synthesis, and also as an inhibitor of enzymes involved in gluconeogenesis; used primarily for treatment of islet cell carcinoma of the pancreas and other endocrine tumors including gastrinomas associated with zollinger-ellison syndrome and glucagon-secreting alpha cell tumors of the pancreas.streptozocin (strĕp′tə-zō′sĭn)n. See streptozotocin. |