| 释义 |
single nucleotide polymorphism
Thesaurus| Noun | 1. | single nucleotide polymorphism - (genetics) genetic variation in a DNA sequence that occurs when a single nucleotide in a genome is altered; SNPs are usually considered to be point mutations that have been evolutionarily successful enough to recur in a significant proportion of the population of a speciesSNPgenetic science, genetics - the branch of biology that studies heredity and variation in organismspolymorphism - (genetics) the genetic variation within a population that natural selection can operate on |
single nucleotide polymorphism
single nucleotide polymorphism[¦siŋ·gəl ¦nü·klē·ə‚tīd ‚päl·ē′mȯr·fiz·əm] (genetics) A single base-pair difference between two copies of a deoxyribonucleic acid sequence from two individuals. Abbreviated SNP. single nucleotide polymorphism
polymorphism [pol″e-mor´fizm] the ability to exist in several different forms.balanced polymorphism an equilibrium mixture of homozygotes and heterozygotes maintained by natural selection against both homozygotes.genetic polymorphism the occurrence together in the same population of two or more genetically determined phenotypes in such proportions that the rarest of them cannot be maintained merely by recurrent mutation.single nucleotide polymorphism (SNP) a genetic polymorphism between two genomes that is based on deletion, insertion, or exchange of a single nucleotide.single nucleotide polymorphism (SNP), the naturally occurring substitution of a single nucleotide at a given location in the genome of an organism, the more interesting of which results in phenotypic variability, including alterations in the organism's physiologic responses to endogenous hormones and neurotransmitters or endogenous substances.single nucleotide polymorphism (SNP, ‘snip’) a single BASE PAIR position in genomic DNA where different sequence alternatives exist for normal individuals in the population. Differences between individual genomes are largely due to SNPs. Over 1.4 million SNPs have been identified in the human GENOME. SNPs in coding regions of the genome are designated cSNPs; those in regulatory regions, rSNPs; and those in JUNK DNA regions, anonymous SNPs. SNPs generate variability, particularly where they occur in coding regions, thereby contributing to the biological characteristics of an individual. For example SNPs reflect differences in susceptibility to, and protection from, a range of diseases. An SNP can be detected by OLIGONUCLEOTIDE HYBRIDIZATION, using for example DNA CHIPS.single nucleotide polymorphism
Synonyms for single nucleotide polymorphismnoun (genetics) genetic variation in a DNA sequence that occurs when a single nucleotide in a genome is alteredSynonymsRelated Words- genetic science
- genetics
- polymorphism
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