well-differentiated liposarcoma


well-differentiated liposarcoma

A well-circumscribed, slow-growing, low-grade malignancy of fat cells, which arises de novo (i.e., not from pre-existing lipomas) in deep soft tissue of thighs, retroperitoneum, and groin of middle-aged adults. As a general rule, the deeper the tumour, the more likely it is to recur.
Epidemiology
5000 new cases/year (US), which is 20% of all soft-tissue tumours; average age 50, slightly more common in males.
Clinical findings
Mass, history of trauma, swelling, reduced range of motion, increased varicose veins, fatigue, abdominal pain, nausea, vomiting, weight loss, compartment syndrome.