Anticancer Drugs

Definition

Anticancer, or antineoplastic, drugs are used to treat malignancies, or cancerous growths. Drug therapy may be used alone, or in combination with other treatments such as surgery or radiation therapy.

Purpose

Anticancer drugs are used to control the growth of cancerous cells. Cancer is commonly defined as the uncontrolled growth of cells, with loss of differentiation and commonly, with metastasis, spread of the cancer to other tissues and organs. Cancers are malignant growths. In contrast, benign growths remain encapsulated and grow within a well-defined area. Although benign tumors may be fatal if untreated, due to pressure on essential organs, as in the case of a benign brain tumor, surgery or radiation are the preferred methods of treating growths which have a well defined location. Drug therapy is used when the tumor has spread, or may spread, to all areas of the body.

Description

Several classes of drugs may be used in cancer treatment, depending on the nature of the organ involved. For example, breast cancers are commonly stimulated by estrogens, and may be treated with drugs that inactivate the sex hormones. Similarly, prostate cancer may be treated with drugs that inactivate androgens, the male sex hormone. However, the majority of antineoplastic drugs act by interfering with cell growth. Since cancerous cells grow more rapidly than other cells, the drugs target those cells that are in the process of reproducing themselves. As a result, antineoplastic drugs will commonly affect not only the cancerous cells, but others cells that commonly reproduce quickly, including hair follicles, ovaries and testes, and the blood-forming organs.Newer methods of antineoplastic drug therapy have taken different approaches, including angiogenesis—the inhibition of formation of blood vessels feeding the tumor and contributing to tumor growth. Although these approaches hold promise, they are not yet in common use. Developing new anticancer drugs is the work of ongoing research. In 2003, a new technique was developed to streamline the search for effective drugs. Researchers pumped more than 23,000 chemical compounds through a screening technique to identify those that help fight cancer while leaving healthy cells unharmed. The system identified nine compounds matching the profile, including one previously unidentified drug for fighting cancer. They have expanded their research to determine how the drug might be developed. This was an important step

Anti Cancer Drugs
Generic (Brand Name)	Clinical Uses	Common Side Effects To Drug
Altretamine (Hexalen)	Treatment of advanced ovarian cancer	Bone marrow depression, nausea and vomiting
Asparaginase (Elspar)	Commonly used in combination with other drugs; refrac- tory acute lymphocy- tic leukemia	Liver, kidney, pancreas, CNS abnormalities,
Bleomycin (Blenoxane)	Lymphomas, Hodgkin's disease, testicular cancer	Hair loss, stomatitis, pulmonary toxicity, hyperpigmentation of skin
Busulfan (Myleran)	Chronic granulocytic leukemia	Bone marrow depression, pulmonary toxicity
Carboplatin (Paraplatin)	Pallilation of ovarian cancer	Bone marrow depression, nausea and vomiting
Carmustine	Hodgkin's disease, brain tumors, multi- ple myeloma, malig- nant melonoma	Bone marrow depression, nausea and vomiting, toxic damage to liver
Chlorambucil (Leukeran)	Chronic lymphocytic leukemia, non- Hodgkin's lymphomas, breast and ovarian cancer	Bone marrow depression, excess uric acid in blood
Cisplatin (Platinol)	Treatment of bladder, ovarian, uterine, testicular, head and neck cancers	Renal toxicity and ototoxicity
Cladribine (Leustatin)	Hairy cell leukemia	Bone marrow depression, nausea and vomiting, fever
Cyclophosphamide (Cytoxan)	Hodgkin's disease, non-Hodgkin's lym- phomas, neuroblas- toma. Often used with other drugs for breast, ovarian, and lung cancers; acute lymphoblastic leuke- mia in children; mul- tiple myeloma	Bone marrow depression, hair loss, nausea and vomiting, inflammation of the bladder
Cytarabine (Cytosar-U)	Leukemias occurring in adults and children	Bone marrow depression, nausea and vomiting, diarrhea, stomatitis
Dacarbazine (DTIC- Dome)	Hodgkin's disease, malignant melanoma	Bone marrow depression, nausea and vomiting
Diethylstilbestrol (DES) (Stilbestrol)	Breast cancer in post-menopausal women, prostate cancer	Hair loss, nausea and vomiting, edema, excess calcium in blood; feminizing effects in men
Ethinyl estradiol (Estinyl)	Advanced breast cancer in post- menopausal women, prostate cancer	Excess calcium in blood, anorexia, edema, nausea and vomiting; feminizing effects in men
Etoposide (VePesid)	Acute leukemias, lymphomas, testicu- lar cancer	Bone marrow depression, nausea and vomiting, hair loss

Anti Cancer Drugs (continued)
Generic (Brand Name)	Clinical Uses	Common Side Effects to Drug
Mitomycin (Mutamycin)	Bladder, breast, colon, lung, pancreas, rectum cancers, head and neck cancer, malig- nant melanoma	Bone marrow depression, nausea and vomiting, diarrhea, stomatitis, possible tissue damage
Mitotane (Lysodren)	Cancer of the adrenal cortex (inoperable)	Damage to adrenal cortex, nausea, anorexia
Mitoxantrone (Novantrone)	Acute nonlymphocy- tic leukemia	Cardiac arrhythmias, labored breating, nausea and vomiting, diarrhea, fever, congestive heart failure
Paclitaxel (Taxol)	Advanced ovarian cancer	Bone marrow depression, hair loss, nausea and vomiting, hypotension, allergic reactions, slow heart action, muscle and joint pain
Pentastatin (Nipent)	Hairy cell leukemia unresponsive to alpha-interferon	Bone marrow depression, fever, skin rash, liver damage, nausea and vomiting
Pipobroman (Vercyte)	Chronic granulocytic leukemia	Bone marrow depression
Plicamycin (Mithracin)	Testucular tumors	Toxicity/damage to bone marrow, kidneys, and liver
Prednisone (Meticorten)	Used in adjunct ther- apy for palliation of symptoms in lympho- mas, acute leukemia Hodgkin's disease	May be toxic to all body systems
Procarbazine (Matulane)	Hodgkin's disease	Bone marrow depression, nausea and vomiting
Streptozocin (Zanosar)	Islet cell carcinoma of pancreas	Nausea and vomiting, toxicity to kidneys
Tamoxifen (Nolvadex)	Advanced breast can- cer in post menopausal	Nausea and vomiting, ocular toxicity, hot flashes
Teniposide (Vumon)	Acute lymphocytic leukemia in children	See Etoposide
Vinblastine (Velban)	Breast cancer, Hodgkin's disease, metastatic testicular cancer	Bone marrow depression, neurotoxicity
Vincristine (Oncovin)	Acute leukemia, Hodgkin's disease, lymphomas	Constipation, neurotoxicity, possible tissue necrosis

Antineoplastic drugs may be divided into two classes: cycle specific and non-cycle specific. Cycle specific drugs act only at specific points of the cell's duplication cycle, such as anaphase or metaphase, while non-cycle specific drugs may act at any point in the cell cycle. In order to gain maximum effect, antineoplastic drugs are commonly used in combinations.

Precautions

Because antineoplastic agents do not target specific cell types, they have a number of common adverse side effects. Hair loss is common due to the effects on hair follicles, and anemia, immune system impairment, and clotting problems are caused by destruction of the blood-forming organs, leading to a reduction in the number of red cells, white cells, and platelets. Because of the frequency and severity of these side effects, it is common to administer chemotherapy in cycles, allowing time for recovery from the drug effects before administering the next dose. Doses are often calculated, not on the basis of weight, but rather based on blood counts, in order to avoid dangerous levels of anemia (red cell depletion), neutropenia (white cell deficiency), or thrombocytopenia (platelet deficiency.)The health professional has many responsibilities in dealing with patients undergoing chemotherapy. The patient must be well informed of the risks and benefits of chemotherapy, and must be emotionally prepared for the side effects. These may be permanent, and younger patients should be aware of the high risk of sterility after chemotherapy.The patient must also know which side effects should be reported to the practitioner, since many adverse effects do not appear until several days after a dose of chemotherapy. When chemotherapy is self-administered, the patient must be familiar with proper use of the drugs, including dose scheduling and avoidance of drug-drug and food-drug interactions.Appropriate steps should be taken to minimize side effects. These may include administration of antinauseant medications to reduce nausea and vomiting, maintaining fluid levels to reduce drug toxicity, particularly to the kidneys, or application of a scalp tourniquet to reduce blood flow to the scalp and minimize hair loss due to drug therapy.Patients receiving chemotherapy also are at risk of infections due to reduced white blood counts. While prophylactic antibiotics may be useful, the health care professional should also be sure to use standard precautions, including gowns and gloves when appropriate. Patients should be alerted to avoid risks of viral contamination, and live virus immunizations are contraindicated until the patient has fully recovered from the effects of chemotherapy. Similarly, the patient should avoid contact with other people who have recently had live virus immunizations.Other precautions which should be emphasized are the risks to pregnant or nursing women. Because antineoplastic drugs are commonly harmful to the fetus, women of childbearing potential should be cautioned to use two effective methods of birth control while receiving cancer chemotherapy. This also applies if the woman's male partner is receiving chemotherapy. Breastfeeding should be avoided while the mother is being treated.

Key terms

Cataract — Clouding of the lens of the eye, leading to poor vision or blindness.Impotent — Unable to achieve or maintain an erection of the penis.Before prescribing or administering anticancer drugs, health care providers should inquire whether the patient has any of the following conditions:

chickenpox or recent exposure to someone with chickenpox
shingles (Herpes zoster)
mouth sores
current or past seizures
head injury
nerve or muscle disease
hearing problems
infection of any kind
gout
colitis
intestine blockage
stomach ulcer
kidney stones
kidney disease
liver disease
current or past alcohol abuse

immune system disease
cataracts or other eye problems
high cholesterol

Other precautions

The anticancer drug methotrexate has additional precautions. Patients should be given advice on the effects of sun exposure and the use of alcohol and pain relievers.

Side effects

Tamoxifen

The anticancer drug tamoxifen (Nolvadex) increases the risk of cancer of the uterus in some women. It also causes cataracts and other eye problems. Women taking this drug may have hot flashes, menstrual changes, genital itching, vaginal discharge, and weight gain. Men who take tamoxifen may lose interest in sex or become impotent. Health care providers should keep in close contact with patients to assess the individual risks associated with taking this powerful drug.

Other anticancer drugs

These side effects are not common, but could be a sign of a serious problem. Health care providers should immediately be consulted if any of the following occur:

black, tarry, or bloody stools
blood in the urine
diarrhea
fever or chills
cough or hoarseness
wheezing or shortness of breath
sores in the mouth or on the lips
unusual bleeding or bruising
swelling of the face
red "pinpoint" spots on the skin
redness, pain, or swelling at the point where an inject-able anticancer drug is given
pain in the side or lower back
problems urinating or painful urination
dizziness or faintness
fast or irregular heartbeat

Other side effects do not need immediate care, but should have medical attention. They are:

joint pain
skin rash
hearing problems or ringing in the ears
numbness or tingling in the fingers or toes
trouble walking or balance problems
swelling of the feet or lower legs
unusual tiredness or weakness
loss of taste
seizures
dizziness
confusion
agitation
headache
dark urine
yellow eyes or skin
flushing of the face

In addition, there are other possible side effects that do not need medical attention unless they persist or interfere with normal activities. These include changes in menstrual period, itchy skin, nausea and vomiting, and loss of appetite.Other rare side effects may occur. Anyone who has unusual symptoms after taking anticancer drugs should contact the physician who prescribed the medication.

Interactions

Anticancer drugs may interact with a number of other medicines. When this happens, the effects of one or both of the drugs may change or the risk of side effects may be greater. The health care provider should be aware of all other prescription or non-prescription (over-the-counter) medicines a patient is taking. The primary care provider should also be told if the patient has been treated with radiation or has taken other anticancer drugs.

Resources

Periodicals

"Technique Streamlines Search for Anticancer Drugs." Cancer Weekly April 15, 2003: 62.