Acid Vesicle System

An intracellular molecular complex, which is present in nucleated mammalian cells, formed by receptor-mediated endocytosis, in which a ligand—molecule being internalised—is bound to receptors that cluster in specialised submembranous regions (pits), which are “coated” by a protein, clathrin; once internalised, the vesicles are acidified, releasing the bound protein.
Types of acid vesicles Coated vesicles (receptor-mediated macromolecule transport from the cell surface), endosomes (macromolecule sorting), lysosomes (degradation of internalised macromolecules) and Golgi complex
Correlates AVS defects are implicated in familial hypercholesterolemia, myotonic dystrophy, I-cell disease, type III mucolipidosis, and infections—e.g., chlamydial, Legionella spp, nocardiosis, toxoplasmosis, chloroquine-resistant malaria NEJM 1987; 317:542rv; at pH 5-5.6, the ligand dissociates from its receptor; subcellular structures may also form as a result of lysosomal enzyme targeting similar to receptor-mediated endocytosis, but it is poorly understood.

单词	acid vesicle system
释义	Acid Vesicle System Acid Vesicle System An intracellular molecular complex, which is present in nucleated mammalian cells, formed by receptor-mediated endocytosis, in which a ligand—molecule being internalised—is bound to receptors that cluster in specialised submembranous regions (pits), which are “coated” by a protein, clathrin; once internalised, the vesicles are acidified, releasing the bound protein. Types of acid vesicles Coated vesicles (receptor-mediated macromolecule transport from the cell surface), endosomes (macromolecule sorting), lysosomes (degradation of internalised macromolecules) and Golgi complex Correlates AVS defects are implicated in familial hypercholesterolemia, myotonic dystrophy, I-cell disease, type III mucolipidosis, and infections—e.g., chlamydial, Legionella spp, nocardiosis, toxoplasmosis, chloroquine-resistant malaria NEJM 1987; 317:542rv; at pH 5-5.6, the ligand dissociates from its receptor; subcellular structures may also form as a result of lysosomal enzyme targeting similar to receptor-mediated endocytosis, but it is poorly understood.
随便看	accessory ovary accessory oviduct accessory pancreas accessory pancreatic duct accessory parathyroid gland accessory parotid gland accessory pathway accessory phrenic nerves accessory pigment accessory pigments accessory placenta accessory plantar ligaments accessory plate accessory portion of spinal accessory nerve accessory power supply accessory process of lumbar vertebra accessory protein accessory pulmonary blood flow accessory quadrate cartilage accessory receptor accessory root canal accessory root of tooth antichoice antichoicer anticholagogue