Bite Cell

An erythrocyte formed when haemoglobin denatures—as occurs in alpha-thalassemia or G6PD deficiency—and precipitates—due to oxidation—into clumps (Heinz bodies) that stick to the red cell membrane; the spleen ‘pits out’ a fragment of membrane with precipitated haemoglobin as the cells pass through the sinusoids, hence the term ‘bite’