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DictionarySeecycleCori Cycle
Cori Cycle an economical method of using carbohydrates; a carbohydrate cycle in animals and man involving the muscles, blood, and liver, investigated by the American biochemist C. Cori in the 1930’s. An increased amount of lactic acid is produced during intense muscle activity. This lactic acid passes into the blood and, from the blood, into the liver, where it is converted to glycogen. Enzymes in the liver break down the glycogen to glucose. The glucose enters the blood, is taken up by the muscles, and serves to resynthesize glycogen. The Cori cycle, together with neurohumoral regulation of glycogen synthesis and breakdown, ensures an optimum blood-sugar level in the organism. Cori cycle
Co·ri cy·cle (kō'rē), the phases in the metabolism of carbohydrate: 1) glycogenolysis in the liver; 2) passage of glucose into the circulation; 3) deposition of glucose in the muscles as glycogen; 4) glycogenolysis during muscular activity and conversion to lactate, which is converted to glycogen in the liver. Also called lactic acid cycle. Synonym(s): lactic acid cycle [Carl F. Cori] Co·ri cy·cle (kō'rē sī'kĕl) The phases in the metabolism of carbohydrate: 1) glycogenolysis in the liver; 2) passage of glucose into the circulation; 3) deposition of glucose in the muscles as glycogen; and 4) glycogenolysis during muscular activity and conversion to lactate, which is converted to glycogen in the liver. [Carl F. Cori]Cori cycle a biochemical pathway that enables lactic acid produced in the skeletal muscles after exercise to be converted in the liver by GLUCONEOGENESIS to form glucose. The new glucose can either be passed back to muscles via the bloodstream to serve as an energy source, or be stored in the liver as glycogen. The two-way flow of products between muscle and liver was first described by Carl Cori (1896–1984).Cori, Carl F., Czech-U.S. biochemist and Nobel laureate, 1896-1984. Cori cycle - the phases in the metabolism of carbohydrate.Cori ester - an important intermediate in glycogenesis and glycogenolysis. Synonym(s): D-glucose 1-phosphateFinancialSeeCycle |