| 单词 | cyanocobalamin | |||
| 释义 | cyanocobalamincy·a·no·co·bal·a·minC0832500 (sī′ə-nō′kō-băl′ə-mĭn, sī-ăn′ō-)cyanocobalamin(ˌsaɪənəʊkəʊˈbæləmɪn) orcyanocobalaminevitamin B1n. vitamin B2n. vitamin B3n. vitamin B6n. vitamin B12n.
cyanocobalamincyanocobalamin:see coenzymecoenzyme, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in ..... Click the link for more information. ; vitaminvitamin, group of organic substances that are required in the diet of humans and animals for normal growth, maintenance of life, and normal reproduction. Vitamins act as catalysts; very often either the vitamins themselves are coenzymes, or they form integral parts of coenzymes. ..... Click the link for more information. . Cyanocobalamin(or Vitamin B12), C63H88CoN14O14P, a cobalt-corrin complex in which the cobalt atom is bonded to a cyano group, a nucleotide residue, and four reduced pyrrole rings; molecular weight, 1355.40. Cyanocobalamin is a dark-red crystalline compound, which is soluble in water and polar organic solvents. It was first isolated in crystalline form from cattle liver. Its structure was established by A. Todd and D. Crowfoot Hodgkin and their co-workers.
The primary sources of cyanocobalamin in nature are microorganisms; cyanocobalamin is synthesized by several bacteria, by actinomycetes, and by blue-green algae. It occurs in almost all animal tissues. It is not encountered, as a rule, in the tissues of higher plants (legume tubers are an exception). In ruminants, it is synthesized in sufficient amounts by the microflora of the intestine and the rumen. In man and several higher animals, such as birds and hogs, its synthesis by intestinal microflora is insufficient, and thus the vitamin must be obtained from food. The daily requirement for humans is about 5 μg. The major sources of the vitamin are liver, kidneys, fish meal, and milk. In the form of its coenzymes methylcobalamin and deoxyadenosylcobalamin, cyanocobalamin participates in the enzymic reactions involved in hematopoiesis and facilitates normal liver function and nerve fiber regeneration. It is produced by microbiological synthesis using propionic-acid bacteria for the fermentation process. Vitamin B12 is used for the treatment of pernicious anemia and other anemias, as well as of diseases of the central and peripheral nervous systems and the liver. It is prescribed in solutions for intramuscular injections. (See alsoVITAMINS; ANEMIA; and COBALAMINS.) REFERENCESSmith, L. Vitamin B12. Moscow, 1962. (Translated from English.)Friedrich, W. Vitamin B12 und Verwandte Corrinoide, 3rd ed. Stuttgart, 1975. I. P. RUDAKOVA cyanocobalamin[¦sī·ə·nō·kō′bal·ə·mən]cyanocobalamincyanocobalamin[si″ah-no-ko-bal´ah-min]cy·a·no·co·bal·a·min(sī'an-ō-kō-bal'ă-min),cyanocobalamin(sī′ə-nō′kō-băl′ə-mĭn, sī-ăn′ō-)vitamin B12A water-soluble vitamin of animal origin required for DNA synthesis. It is a glycoprotein produced and secreted by the gastric parietal cells, and is absorbed from the GI tract bound to intrinsic factor; the body stores up to one years’ worth of vitamin B12 in the liver, kidneys and heart. Rapid cell turnover (e.g., growth spurts in children, malignancy) require increased amounts of vitamin B12. Vegans, who ingest no protein of animal origin, are at risk for vitamin B12 deficiency.Increased by Chronic myeloid leukaemia, chronic obstructive pulmonary disease, congestive heart failure, liver disease, obesity, polycythemia vera, renal failure. Decreased by Atrophic gastritis, drugs (antibiotics, anticonvulsants, antimalarials, antituberculous agents, chemotherapy, contraceptives, diuretics, oral hypoglycemics, sedatives), inflammatory bowel disease (e.g., Crohn’s disease, ulcerative colitis), intrinsic factor deficiency (causing megaloblastic anaemia), malabsorption, malnutrition, parasites (e.g., Diphyllobotrium latum), veganism. cyanocobalaminVitamin B12 A water soluble B vitamin, central to proper CNS function, and carbohydrate, protein and fat metabolism. See Vitamin B12.cy·a·no·co·bal·a·min(sī'ă-nō-kō-bal'ă-min)cyanocobalaminVitamin B12. This vitamin is necessary for the normal metabolism of carbohydrates, fats and proteins, for blood cell formation and for nerve function. It is used in the treatment of PERNICIOUS ANAEMIA and SPRUE. Brand names are Cytacon and Cytamen.cyanocobalaminsee COBALAMIN.cy·a·no·co·bal·a·min(sī'ă-nō-kō-bal'ă-min)Patient discussion about cyanocobalaminQ. Can a food rich in vitamin B12 will help for his depression or vitamin B12 pills are always required? Hi all…..having one question related to my friends depression and its relation to vitamin B12, as a medicine given to him by his Doctor. Can a food rich in vitamin B12 will help for his depression or vitamin B12 pills are always required? cyanocobalamin
Synonyms for cyanocobalamin
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cyanocobalamin - a B vitamin that is used to treat pernicious anemia