| 释义 |
fragile site
fragile site[′fraj·əl ¦sīt] (genetics) The chromosomal position of a deoxyribonucleic acid sequence predisposed to spontaneous or induced breakage; sometimes contains short repetitive sequences. fragile site
frag·ile site [MIM*136540, MIM*136670] a nonstaining gap at a specific point on a chromosome, usually involving both chromatids, always at the same point on chromosomes of different cells from an individual or kindred; it results in in vitro production of acentric fragments, deleted chromosomes, or other chromosome anomalies; inherited as a dominant chromosome marker.frag·ile site (fraj'il sīt) A nonstaining gap at a specific point on a chromosome, usually involving both chromatids, always at the same point on chromosomes of different cells from an individual or kindred. fragile site a site in a CHROMOSOME where breakage is likely to occur due to the presence of an expanded trinucleotide repeat (see TRINUCLEOTIDE REPEAT EXPANSION DISEASE). |