cyclins


cyclins

(sī′klĭnz) A group of intracellular proteins that regulate the cell cycle, i.e., cell growth and division. Some cyclins, including cyclins D and E, are overexpressed in human breast cancer cells.

cyclins

Regulatory subunits of the kinases involved in the eukaryotic cell cycle. Cyclins are proteins whose concentration in the cells increases and decreases in phase with the cell cycle. Passage through the cycle is controlled by cyclin-dependent kynase complexes which are inactive unless associated with a cyclin.