frameshift

(ˈfreɪmˌʃɪft) na frameshift mutation is a genetic mutation in which a number of nucleotides not divisible by three are either inserted into or deleted from a nucleic acid sequence

frame•shift

(ˈfreɪmˌʃɪft)

n. the addition or deletion of one or more nucleotides in a strand of DNA, which shifts the codon triplets of the genetic code of messenger RNA, resulting in a mutation. [1970–75]

frameshift

frame·shift

(frām'shift), As used in genetics, a mutation that causes a sequence such that the reading frame groups of three bases in mRNA become out of register; the insertion or deletion of one or two bases, for example, would lead to an altered grouping of three bases causing incorrect amino acid residues to be incorporated into growing polypeptide chains, or would signal premature chain termination.

Fig. 165 Frameshift . The effect of inserting an extra DNA base into nucleotide base sequence.

frameshift

an altered reading of the GENETIC CODE during TRANSLATION in PROTEIN SYNTHESIS, caused by a change in the nucleotide base sequence of DNA and RNA due to the insertion or deletion of one or more bases (except three bases or multiples of three bases). Fig. 165 shows an example of a DNA base insertion between bases 4' and 5'. When the sequence is read from left to right the first amino acid is unchanged, but the second and subsequent amino acids will be altered, producing a mutant protein.

单词	frameshift
释义	frameshift frameshift (ˈfreɪmˌʃɪft) na frameshift mutation is a genetic mutation in which a number of nucleotides not divisible by three are either inserted into or deleted from a nucleic acid sequence frame•shift (ˈfreɪmˌʃɪft) n. the addition or deletion of one or more nucleotides in a strand of DNA, which shifts the codon triplets of the genetic code of messenger RNA, resulting in a mutation. [1970–75] EncyclopediaSeeframeshift mutation frameshift frame·shift (frām'shift), As used in genetics, a mutation that causes a sequence such that the reading frame groups of three bases in mRNA become out of register; the insertion or deletion of one or two bases, for example, would lead to an altered grouping of three bases causing incorrect amino acid residues to be incorporated into growing polypeptide chains, or would signal premature chain termination. Fig. 165 Frameshift . The effect of inserting an extra DNA base into nucleotide base sequence. frameshift an altered reading of the GENETIC CODE during TRANSLATION in PROTEIN SYNTHESIS, caused by a change in the nucleotide base sequence of DNA and RNA due to the insertion or deletion of one or more bases (except three bases or multiples of three bases). Fig. 165 shows an example of a DNA base insertion between bases 4' and 5'. When the sequence is read from left to right the first amino acid is unchanged, but the second and subsequent amino acids will be altered, producing a mutant protein.
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