epithelial membrane antigen

epithelial membrane antigen (EMA),

a heavily glycosylated, 70-kD protein complex, first isolated in human milk fat globulin; this antigen is present in a variety of glandular epithelia, especially in breast carcinoma cells but may also be seen in cultured fibroblasts, lymphoid cells, and some stromal cells. Immunohistochemical staining may aid in tissue diagnosis.

epithelial membrane antigen

A 265–400-kD transmembrane glycoprotein found in milk-fat globule membranes.
Normal expression
Normal epithelia and perineurial cells.
Abnormal expression
Neoplastic epithelia and perineurial cells, meningioma, mesothelioma, mesenchymal tumours, some lymphomas, choroid plexus, arachnoid granulation, epithelioid histiocytes, anaplastic large cell lymphomas.

ep·i·the·li·al mem·brane an·ti·gen

(EMA) (ep'i-thē'lē-ăl mem'brān an'ti-jen) A heavily glycosylated, 70-kD protein complex, first isolated in human milk fat globulin; this antigen is present in a variety of glandular epithelia, especially in breast carcinoma cells, but may also be seen in cultured fibroblasts, lymphoid cells, and some stromal cells. Immunohistochemical staining may be used as a diagnostic aid in tissue diagnosis.

单词	epithelial membrane antigen
释义	epithelial membrane antigen epithelial membrane antigen (EMA), a heavily glycosylated, 70-kD protein complex, first isolated in human milk fat globulin; this antigen is present in a variety of glandular epithelia, especially in breast carcinoma cells but may also be seen in cultured fibroblasts, lymphoid cells, and some stromal cells. Immunohistochemical staining may aid in tissue diagnosis. epithelial membrane antigen A 265–400-kD transmembrane glycoprotein found in milk-fat globule membranes. Normal expression Normal epithelia and perineurial cells. Abnormal expression Neoplastic epithelia and perineurial cells, meningioma, mesothelioma, mesenchymal tumours, some lymphomas, choroid plexus, arachnoid granulation, epithelioid histiocytes, anaplastic large cell lymphomas. ep·i·the·li·al mem·brane an·ti·gen (EMA) (ep'i-thē'lē-ăl mem'brān an'ti-jen) A heavily glycosylated, 70-kD protein complex, first isolated in human milk fat globulin; this antigen is present in a variety of glandular epithelia, especially in breast carcinoma cells, but may also be seen in cultured fibroblasts, lymphoid cells, and some stromal cells. Immunohistochemical staining may be used as a diagnostic aid in tissue diagnosis. AcronymsSeeEMA
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