Cosmegen


Cosmegen

 [kos´mĕ-jen] trademark for a preparation of dactinomycin, an antitumor antibiotic.

Cosmegen

(kŏs′mə-jən) A trademark for the drug dactinomycin.

Actinomycin D

A relatively toxic antibiotic produced by Streptomyces spp, which is used as a chemotherapeutic.
Mechanism Inhibits DNA transcription by RNA polymerase.
Indications Rhabdomyosarcoma, Wilms’ tumour, gestational trophoblastic tumour 
Adverse effects Anorexia, nausea, vomiting, myelosuppression with pancytopenia, diarrhoea