Dalmane
| Noun | 1. | Dalmane - tranquilizer (trade name Dalmane) used to treat insomnia |
Dalmane
Dalmane
[dal´mān]flurazepam hydrochloride
Pharmacologic class: Benzodiazepine
Therapeutic class: Sedative-hypnotic
Controlled substance IV
Pregnancy risk category X
Action
Depresses CNS at limbic, thalamic, and hypothalamic levels by enhancing inhibitory neurotransmitter effect of gamma-aminobutyric acid on neuronal excitability
Availability
Capsules: 15 mg, 30 mg
Indications and dosages
➣ Short-term management of insomnia (less than 4 weeks)
Adults: 15 to 30 mg P.O. at bedtime
Dosage adjustment
• Elderly or debilitated patients
Contraindications
• Hypersensitivity to drug or other benzodiazepines
• Preexisting CNS depression
• Angle-closure glaucoma
• Pregnancy or breastfeeding
Precautions
Use cautiously in:
• hepatic dysfunction
• history of suicide attempt or drug dependence
• elderly patients
• children younger than age 15 (safety not established).
Administration
• Before starting therapy, evaluate patient's mental status and check kidney and liver function tests and CBC.
Adverse reactions
CNS: dizziness, daytime drowsiness, headache, lethargy, confusion, poor concentration, depression, paradoxical excitation, ataxia
EENT: blurred vision
GI: nausea, vomiting, diarrhea, constipation, dyspepsia, abdominal pain
Respiratory: sleep apnea
Skin: rash
Other: abnormal taste, hangover, physical or psychological drug dependence, drug tolerance
Interactions
Drug-drug. Antidepressants, antihistamines, opioids: additive CNS depression
Barbiturates, rifampin: increased flurazepam metabolism, decreased efficacy
Cimetidine, disulfiram, fluoxetine, hormonal contraceptives, isoniazid, ketoconazole, metoprolol, propoxyphene, propranolol, valproic acid: decreased flurazepam metabolism, enhanced efficacy
Levodopa: decreased levodopa efficacy
Theophylline: decreased sedative effects of flurazepam
Drug-diagnostic tests. Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, total and direct bilirubin: increased levels
Drug-herbs. Chamomile, hops, kava, skullcap, valerian: additive CNS depression
Drug-behaviors. Alcohol use: additive CNS depression
Smoking: increased drug metabolism and clearance
Patient monitoring
• With long-term use, watch for signs and symptoms of physical or psychological dependence.
• Monitor patient's mental status, especially for depression and suicidal ideation.
• Watch for signs of drug hoarding or overuse.
• Monitor CBC and liver and kidney function tests.
Patient teaching
See Urge patient (and significant other as appropriate) to report signs and symptoms of depression or suicidal thoughts or actions.
See Advise female patient to immediately tell prescriber if she is pregnant. Caution her not to breastfeed.
• Inform patient that drug may cause physical or psychological dependence.
• Advise patient to minimize GI upset by eating frequent, small servings of food and drinking adequate fluids.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.
Dalmane®
See Flurazepam.Dalmane
A brand name for FLURAZEPAM.Dalmane
- noun
Synonyms for Dalmane
noun tranquilizer (trade name Dalmane) used to treat insomnia
Synonyms
- flurazepam
- flurazepam hydrochloride
Related Words
- antianxiety drug
- anxiolytic
- anxiolytic drug
- minor tranquilizer
- minor tranquilliser
- minor tranquillizer
- brand
- brand name
- marque
- trade name
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