factor IX

factor

[fak´ter] an agent or element that contributes to the production of a result.accelerator factor factor V, one of the coagulation factors.factor I see coagulation factors.factor II see coagulation factors.factor III see coagulation factors.factor IV see coagulation factors.factor V see coagulation factors.factor VI see coagulation factors.factor VII see coagulation factors.factor VIII see coagulation factors.factor IX see coagulation factors.factor X see coagulation factors.factor XI see coagulation factors.factor XII see coagulation factors.factor XIII see coagulation factors.angiogenesis factor a substance that causes the growth of new blood vessels, found in tissues with high metabolic requirements such as cancers and the retina. It is also released by hypoxic macrophages at the edges or outer surface of a wound and initiates revascularization in wound healing.antihemophilic factor (AHF) 1. factor VIII, one of the coagulation factors.2. a preparation of factor VIII administered intravenously for the prevention or treatment of hemorrhage in patients with hemophilia A and the treatment of von Willebrand disease, hypofibrinogenemia, and coagulation factor XIII deficiency. Included are preparations derived from human plasma (antihemophilic factor, cryoprecipitated antihemophilic factor) or porcine plasma (antihemophilic factor [porcine]) and those produced by recombinant technology antihemophilic factor [recombinant]).antihemophilic factor A factor VIII, one of the coagulation factors.antihemophilic factor B factor IX, one of the coagulation factors.antihemophilic factor C factor XI, one of the coagulation factors.antihemorrhagic factor vitamin K.antinuclear factor (ANF) antinuclear antibody.antirachitic factor vitamin D.atrial natriuretic factor (ANF) a hormone produced in the cardiac atrium; an inhibitor of renin secretion and thus of the production of angiotensin, and a stimulator of aldosterone release. Its effect is increased excretion of water and sodium and a lowering of blood pressure.factor B a complement component that participates in the alternative complement pathway.blastogenic factor lymphocyte-transforming factor.carative f's in the theory of human caring, a set of ten factors that offer a descriptive topology of interventions including (1) a humanistic-altruistic system of values; (2) faith-hope; (3) sensitivity to self and others; (4) a helping-trusting, human care relationship; (5) the expression of positive and negative feelings; (6) a creative problem-solving caring process; (7) transpersonal teaching and learning; (8) a supportive, protective, and/or corrective mental, physical, societal, and spiritual environment; (9) human needs assistance; and (10) existential-phenomenological-spiritual forces.Christmas factor factor IX, one of the coagulation factors.citrovorum factor folinic acid.clotting f's coagulation factors" >coagulation factors.C3 nephritic factor (C3 NeF) an autoantibody that stabilizes the alternative complement pathway C3 convertase, preventing its inactivation by factor h, resulting in complete consumption of plasma C3; it is found in the serum of many patients with type II glomerulonephritis" >membranoproliferative glomerulonephritis.coagulation f's see coagulation factors.colony-stimulating factor (CSF) any of a number of glycoproteins responsible for the proliferation, differentiation, and functional activation of hematopoietic progenitor cells; specific factors are named for the cell lines that they stimulate. Used to promote bone marrow proliferation in aplastic anemia, following cytotoxic chemotherapy, or following transplantation" >bone marrow transplantation. Types include granulocyte, granulocyte-macrophage, and macrophage colony-stimulating factors.factor D a factor that when activated serves as a serine esterase in the alternative complement pathway.decay accelerating factor (DAF) a protein of most blood as well as endothelial and epithelial cells, CD55 (see CD antigen); it protects the cell membranes from attack by autologous complement.endothelial-derived relaxant factor (endothelial-derived relaxing factor) (endothelium-derived relaxing factor (EDRF)) nitric oxide.extrinsic factor cyanocobalamin.F factor (fertility factor) F plasmid.fibrin-stabilizing factor (FSF) factor XIII, one of the coagulation factors.Fitzgerald factor high-molecular-weight kininogen.Fletcher factor prekallikrein.granulocyte colony-stimulating factor (G-CSF) a factor" >colony-stimulating factor that stimulates production of neutrophils from precursor cells.granulocyte-macrophage colony-stimulating factor (GM-CSF) a factor" >colony-stimulating factor that binds to stem cells and most myelocytes and stimulates their differentiation into granulocytes and macrophages.growth factor any substance that promotes skeletal or somatic growth; usually a mineral, hormone, or vitamin.factor H a complement system regulatory protein that inhibits the alternative pathway of complement activation.Hageman factor (HF) factor XII, one of the coagulation factors. See illustration.

Activation of Hageman factor (factor XII) leads to increased vascular permeability, clotting, and thrombolysis. From Damjanov, 2000.hematopoietic growth f's a group of substances with the ability to support hematopoietic colony formation in vitro, including erythropoietin, interleukin-3, and colony-stimulating factors. All except erythropoietin stimulate mature cells, have overlapping capabilities to affect progenitor cells of several blood cell lines, and also affect cells outside the hematopoietic system.histamine-releasing factor (HRF) a lymphokine, believed to be produced by macrophages and B lymphocytes, that induces the release of histamine by IgE-bound basophils. It occurs in late phase allergic reaction, six or more hours after contact with the antigen, in sensitive individuals.homologous restriction factor (HRF) a regulatory protein that binds to the complex" >membrane attack complex in autologous cells, inhibiting the final stages of complement activation.factor I a plasma enzyme that regulates both classical and alternative pathways of complement activation by inactivating their C3 convertases.immunoglobulin-binding factor (IBF) a lymphokine having the ability to bind IgG complexed with antigen and prevent complement activation.insulinlike growth f's (IGF) insulinlike substances in serum that do not react with insulin antibodies; they are growth hormone–dependent and possess all the growth-promoting properties of the somatomedins.intensification factor in radiology, the comparative increase in light transmission when films are exposed in the presence of intensifying screens compared to that in the absence of screens.intrinsic factor a glycoprotein secreted by the parietal cells of the gastric glands, necessary for the absorption of cyanocobalamin (vitamin B₁₂). Its absence results in pernicious anemia.LE factor an immunoglobulin that reacts with leukocyte nuclei, found in the serum in systemic lupus erythematosus.lymph node permeability factor (LNPF) a substance from normal lymph nodes that produces vascular permeability.lymphocyte mitogenic factor (LMF) (lymphocyte-transforming factor) a substance that is released by lymphocytes stimulated by specific antigen and causes nonstimulated lymphocytes to undergo blast transformation and cell division; called also blastogenic factor.macrophage-activating factor (MAF) interferon-α.macrophage colony-stimulating factor (M-CSF) a factor" >colony-stimulating factor secreted by macrophages, stimulated endothelial cells, and most tissues, that stimulates the production of macrophages from precursor cells and maintains the viability of mature macrophages in vitro.macrophage chemotactic factor (MCF) a lymphokine that attracts macrophages to the invasion site.macrophage-derived growth factor a substance released by macrophages below the surface of a wound that induces the proliferation of fibroblasts.macrophage inhibition factor (macrophage inhibitory factor) migration inhibitory factor.migration inhibition factor (migration inhibitory factor) a lymphokine that inhibits macrophage migration.minification factor in radiology, the gain in light achieved by a reduction in size of the output phosphor from the input phosphor size.osteoclast-activating factor (OAF) a lymphokine that stimulates bone resorption; it may be involved in the bone resorption associated with multiple myeloma and other hematologic neoplasms or inflammatory disorders such as rheumatoid arthritis and periodontal disease.factor P properdin.platelet f's see platelet factors.platelet-activating factor (PAF) a substance released by basophils and mast cells in hypersensitivity" >immediate hypersensitivity reactions, and by macrophages and neutrophils in other inflammatory reactions; it leads to bronchoconstriction, platelet aggregation, and release of vasoactive substances from platelets.platelet-derived growth factor a substance contained in platelets and capable of inducing proliferation of vascular endothelial cells, vascular smooth muscle cells, fibroblasts, and glial cells; its action contributes to the repair of damaged vascular walls.R factor R plasmid.releasing f's factors elaborated in one structure (as in the hypothalamus) that effect the release of hormones from another structure (as from the anterior pituitary gland), including corticotropin-releasing factor, melanocyte-stimulating hormone–releasing factor, and prolactin-releasing factor. Applied to substances of unknown chemical structure, while substances of established chemical identity are called releasing hormones.resistance factor R f.Rh factor a type of agglutinogen found on some erythrocytes; see also rh factor" >rh factor.rheumatoid factor (RF) antibodies directed against antigenic determinants on IgG molecules, found in the serum of about 80 per cent of patients with classic or definite rheumatoid arthritis; but in only about 20 per cent of patients with juvenile rheumatoid arthritis; rheumatoid factors may be IgM, IgG, or IgA antibodies, although serologic tests measure only IgM. Rheumatoid factors also occur in other connective tissue diseases and infectious diseases.risk factor an agent or situation that is known to make an individual or population more susceptible to the development of a specific negative condition.risk factor (omaha) an environmental, psychosocial, or physiologic event or health related behavior that increases the client's exposure or vulnerability to the development of a client problem; the nurse's knowledge base of risk factors is used to identify potential modifiers" >problem modifiers in the scheme" >Problem Classification scheme of the omaha system." >omaha system.stable factor factor VII, one of the coagulation factors.Stuart factor (Stuart-Prower factor) factor X, one of the coagulation factors.sun protection factor (SPF) a numerical rating of the amount of protection afforded by a sunscreen; the higher the number, the more protection is provided.tissue factor factor III, one of the coagulation factors.transfer factor (TF) a factor occurring in sensitized lymphocytes that can transfer delayed hypersensitivity to a formerly nonreactive individual; see also transfer factor.tumor necrosis factor (TNF) either of two lymphokines produced primarily by cells of the immune system, capable of causing in vivo hemorrhagic necrosis of certain tumor cells but not normal cells. They also destroy cells associated with the response" >inflammatory response. They have been used as experimental anticancer agents but can also induce shock when bacterial endotoxins cause their release. Tumor necrosis factor α, formerly called cachectin, contains 157 amino acids and is produced by macrophages, eosinophils, and NK cells. Tumor necrosis factor β is lymphotoxin and contains 171 amino acids.vascular endothelial growth factor (VEGF) (vascular permeability factor (VPF)) a peptide factor that stimulates the proliferation of cells of the endothelium of blood vessels; it promotes tissue vascularization and is important in blood vessel formation in tumors. von Willebrand's factor (vWF) a glycoprotein synthesized in endothelial cells and megakaryocytes that circulates complexed to coagulation factor VIII. It is involved in adhesion of platelets to damaged epithelial surfaces and may participate in platelet aggregation. Deficiency results in the prolonged bleeding time seen in von Willebrand's disease.

factor IX (human)

AlphaNine SD, Immune VH (CA), Mononine

factor IX (recombinant)

BeneFix

factor IX complex

Bebulin VH, Defix (UK), Hipfix (UK), Octaplex (CA), Profilnine SD, Proplex T (heat-treated), Replenine (UK)

Pharmacologic class: Blood modifier

Therapeutic class: Antihemophilic

Pregnancy risk category C

Action

Converts fibrinogen to fibrin, increasing levels of clotting factors

Availability

Powder for injection: Various strengths; units specified on label

Indications and dosages

➣ Factor IX deficiency (hemophilia B or Christmas disease); anticoagulant overdose

Adults and children: Dosage individualized; drug administered I.V. Use following equations to calculate approximate units needed:

Human product-1 unit/kg times body weight (in kg) times desired increase in factor IX level, expressed as percentage of normal

Recombinant product-1.2 units/kg times body weight (in kg) times desired increase in factor IX level, expressed as percentage of normal

Proplex T-0.5 unit/kg times body weight (in kg) times desired increase in factor IX level, expressed as percentage of normal

Off-label uses

• Hepatic dysfunction

• Esophagitis

• Unspecified GI hemorrhage (human product)

Contraindications

• Hypersensitivity to mouse or hamster protein (with BeneFix)

• Fibrinolysis

Precautions

Use cautiously in:

• recent surgery

• pregnant patients

• children younger than age 6 (safety and efficacy not established).

Administration

See Give by slow I.V. infusion. Average infusion rate is 100 units (2 to 3 ml)/minute; don't exceed 10 ml/minute.

• If prescribed, administer hepatitis B vaccine before giving factor IX.

• Know that dosage is highly individualized according to degree of factor IX deficiency, patient's weight, and bleeding severity.

• Don't use glass syringe. Don't shake reconstituted solution or mix with other I.V. solutions.

Adverse reactions

CNS: light-headedness, paresthesia, headache

CV: blood pressure changes, thromboembolic reactions, myocardial infarction (MI)

EENT: allergic rhinitis

GI: nausea, vomiting

Hematologic: disseminated intravascular coagulation (DIC)

Respiratory: pulmonary embolism

Skin: rash, flushing, diaphoresis, pruritus, urticaria

Other: altered taste, fever, chills, burning sensation in jaw and skull, pain at I.V. injection site, hypersensitivity reactions including anaphylaxis

Interactions

Drug-drug. Aminocaproic acid: increased risk of thrombosis

Patient monitoring

• Be aware that factor IX complex may transmit hepatitis.

• Closely monitor vital signs during infusion.

See Observe for hemolytic reaction. If it occurs, stop infusion, flush line with saline solution, and notify prescriber immediately.

• Monitor I.V. injection site closely.

See Monitor coagulation studies closely. Know that drug may cause thromboembolic disorders, including MI and DIC.

Patient teaching

• Inform patient that drug may transmit diseases.

See Tell patient to immediately report signs and symptoms of hypersensitivity reaction, including rash, hives, tightness in chest, wheezing, shortness of breath, and swelling of throat or lips.

See Advise patient to immediately report unusual bleeding or bruising.

• Caution patient to avoid activities that can cause injury.

• Tell patient to wear medical identification stating that he has a blood-clotting disorder.

• Instruct patient to notify surgeon or dentist of his blood-clotting disorder before surgery or invasive dental procedures.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs mentioned above.

fac·tor IX

in the clotting of blood, also known as: Christmas factor (Biggs and Macfarlane), plasma thromboplastin component (Aggeler), antihemophilic globulin B (Cramer), plasma thromboplastin factor B (Aggeler), plasma factor X (Shulman), antihemophilic factor B, and platelet cofactor II. Factor IX is required for the formation of intrinsic blood thromboplastin and affects the amount formed (rather than the rate). Its active form, factor IXa (EC 3.4.21.22) is a serine proteinase converting factor X to factor Xa by cleaving an arginine-isoleucine bond. Deficiency of factor IX causes hemophilia B. Synonym(s): antihemophilic factor B, antihemophilic globulin B, Christmas factor, plasma factor X, plasma thromboplastin component, plasma thromboplastin factor B, platelet cofactor II

factor IX

n. A protein substance in blood plasma that is essential for the clotting of blood. A deficiency of this factor is the cause of Christmas disease.

factor IX

Christmas factor, coagulation factor IX Hematology An intrinsic pathway factor which, when activated–IXa, combines with Factor VIII and a phospholipid to activate Factor X in the common pathway. See Common pathway, Factor IX deficiency.

fac·tor IX

(fak'tŏr) In the clotting of blood, required for the formation of intrinsic blood thromboplastin; deficiency causes hemophilia B.
Synonym(s): antihemophilic globulin B, Christmas factor, plasma thromboplastin component.

factor IX

One of the many factors necessary for blood clotting. Absence of factor IX occurs as a result of an X-LINKED gene mutation and causes Christmas disease, a form of HAEMOPHILIA almost identical to factor VIII deficiency haemophilia. The drug is on the WHO official list. Human coagulation Factor IX is produced in freeze-dried form derived from donated blood under the brand names Mononine and Replenine.

fac·tor IX

(fak'tŏr) In blood clotting, also known as: Christmas factor and other designations; required for formation of intrinsic blood thromboplastin and affects the amount formed (rather than the rate).

factor IX

factor IX

factor IX

factor IX

factor IX

factor

factor IX (human)

factor IX (recombinant)

factor IX complex

Action

Availability

Indications and dosages

Off-label uses

Contraindications

Precautions

Administration

Adverse reactions

Interactions

Patient monitoring

Patient teaching

fac·tor IX

factor IX

factor IX

fac·tor IX

factor IX

fac·tor IX

factor IX

Synonyms for factor IX

noun coagulation factor whose absence is associated with hemophilia B

Synonyms

Related Words