alkaline phosphatase isoenzyme


alkaline phosphatase isoenzyme

Any of the organ-specific alkaline phosphatase isoenzymes: liver, bone, intestine and placenta. Intestinal AP occurs almost exclusively in individuals with blood group B or O and is increased 8 hours after a fatty meal; placental AP first appears in the 2nd trimester of pregnancy, accounts for half of all AP in the 3rd trimester and drops to normal levels 1 month postpartum; the Regan isoenzyme resembles the placental AP and is present in some patients with cancer. APIs should not be measured if the total AP levels are within the lab’s reference range, as the results have little significance; these tests are only semi-quantitative and are variable.

alkaline phosphatase isoenzyme

Clinical chemistry Any of the organ-specific alkaline phosphatase isoenzymes: liver, bone, intestine and placenta; intestinal AP occurs almost exclusively in individuals with blood group B or O and is ↑ 8 hrs after a fatty meal; placental AP first appears in the 2nd trimester of pregnancy, accounts for half of all AP in the 3rd trimester and drops to normal levels 1 month post partum; the Regan isoenzyme resembles the placental AP and is present in some Pts with cancer. See Alkaline phosphatase.