factor VIII

factor

[fak´ter] an agent or element that contributes to the production of a result.accelerator factor factor V, one of the coagulation factors.factor I see coagulation factors.factor II see coagulation factors.factor III see coagulation factors.factor IV see coagulation factors.factor V see coagulation factors.factor VI see coagulation factors.factor VII see coagulation factors.factor VIII see coagulation factors.factor IX see coagulation factors.factor X see coagulation factors.factor XI see coagulation factors.factor XII see coagulation factors.factor XIII see coagulation factors.angiogenesis factor a substance that causes the growth of new blood vessels, found in tissues with high metabolic requirements such as cancers and the retina. It is also released by hypoxic macrophages at the edges or outer surface of a wound and initiates revascularization in wound healing.antihemophilic factor (AHF) 1. factor VIII, one of the coagulation factors.2. a preparation of factor VIII administered intravenously for the prevention or treatment of hemorrhage in patients with hemophilia A and the treatment of von Willebrand disease, hypofibrinogenemia, and coagulation factor XIII deficiency. Included are preparations derived from human plasma (antihemophilic factor, cryoprecipitated antihemophilic factor) or porcine plasma (antihemophilic factor [porcine]) and those produced by recombinant technology antihemophilic factor [recombinant]).antihemophilic factor A factor VIII, one of the coagulation factors.antihemophilic factor B factor IX, one of the coagulation factors.antihemophilic factor C factor XI, one of the coagulation factors.antihemorrhagic factor vitamin K.antinuclear factor (ANF) antinuclear antibody.antirachitic factor vitamin D.atrial natriuretic factor (ANF) a hormone produced in the cardiac atrium; an inhibitor of renin secretion and thus of the production of angiotensin, and a stimulator of aldosterone release. Its effect is increased excretion of water and sodium and a lowering of blood pressure.factor B a complement component that participates in the alternative complement pathway.blastogenic factor lymphocyte-transforming factor.carative f's in the theory of human caring, a set of ten factors that offer a descriptive topology of interventions including (1) a humanistic-altruistic system of values; (2) faith-hope; (3) sensitivity to self and others; (4) a helping-trusting, human care relationship; (5) the expression of positive and negative feelings; (6) a creative problem-solving caring process; (7) transpersonal teaching and learning; (8) a supportive, protective, and/or corrective mental, physical, societal, and spiritual environment; (9) human needs assistance; and (10) existential-phenomenological-spiritual forces.Christmas factor factor IX, one of the coagulation factors.citrovorum factor folinic acid.clotting f's coagulation factors" >coagulation factors.C3 nephritic factor (C3 NeF) an autoantibody that stabilizes the alternative complement pathway C3 convertase, preventing its inactivation by factor h, resulting in complete consumption of plasma C3; it is found in the serum of many patients with type II glomerulonephritis" >membranoproliferative glomerulonephritis.coagulation f's see coagulation factors.colony-stimulating factor (CSF) any of a number of glycoproteins responsible for the proliferation, differentiation, and functional activation of hematopoietic progenitor cells; specific factors are named for the cell lines that they stimulate. Used to promote bone marrow proliferation in aplastic anemia, following cytotoxic chemotherapy, or following transplantation" >bone marrow transplantation. Types include granulocyte, granulocyte-macrophage, and macrophage colony-stimulating factors.factor D a factor that when activated serves as a serine esterase in the alternative complement pathway.decay accelerating factor (DAF) a protein of most blood as well as endothelial and epithelial cells, CD55 (see CD antigen); it protects the cell membranes from attack by autologous complement.endothelial-derived relaxant factor (endothelial-derived relaxing factor) (endothelium-derived relaxing factor (EDRF)) nitric oxide.extrinsic factor cyanocobalamin.F factor (fertility factor) F plasmid.fibrin-stabilizing factor (FSF) factor XIII, one of the coagulation factors.Fitzgerald factor high-molecular-weight kininogen.Fletcher factor prekallikrein.granulocyte colony-stimulating factor (G-CSF) a factor" >colony-stimulating factor that stimulates production of neutrophils from precursor cells.granulocyte-macrophage colony-stimulating factor (GM-CSF) a factor" >colony-stimulating factor that binds to stem cells and most myelocytes and stimulates their differentiation into granulocytes and macrophages.growth factor any substance that promotes skeletal or somatic growth; usually a mineral, hormone, or vitamin.factor H a complement system regulatory protein that inhibits the alternative pathway of complement activation.Hageman factor (HF) factor XII, one of the coagulation factors. See illustration.

Activation of Hageman factor (factor XII) leads to increased vascular permeability, clotting, and thrombolysis. From Damjanov, 2000.hematopoietic growth f's a group of substances with the ability to support hematopoietic colony formation in vitro, including erythropoietin, interleukin-3, and colony-stimulating factors. All except erythropoietin stimulate mature cells, have overlapping capabilities to affect progenitor cells of several blood cell lines, and also affect cells outside the hematopoietic system.histamine-releasing factor (HRF) a lymphokine, believed to be produced by macrophages and B lymphocytes, that induces the release of histamine by IgE-bound basophils. It occurs in late phase allergic reaction, six or more hours after contact with the antigen, in sensitive individuals.homologous restriction factor (HRF) a regulatory protein that binds to the complex" >membrane attack complex in autologous cells, inhibiting the final stages of complement activation.factor I a plasma enzyme that regulates both classical and alternative pathways of complement activation by inactivating their C3 convertases.immunoglobulin-binding factor (IBF) a lymphokine having the ability to bind IgG complexed with antigen and prevent complement activation.insulinlike growth f's (IGF) insulinlike substances in serum that do not react with insulin antibodies; they are growth hormone–dependent and possess all the growth-promoting properties of the somatomedins.intensification factor in radiology, the comparative increase in light transmission when films are exposed in the presence of intensifying screens compared to that in the absence of screens.intrinsic factor a glycoprotein secreted by the parietal cells of the gastric glands, necessary for the absorption of cyanocobalamin (vitamin B₁₂). Its absence results in pernicious anemia.LE factor an immunoglobulin that reacts with leukocyte nuclei, found in the serum in systemic lupus erythematosus.lymph node permeability factor (LNPF) a substance from normal lymph nodes that produces vascular permeability.lymphocyte mitogenic factor (LMF) (lymphocyte-transforming factor) a substance that is released by lymphocytes stimulated by specific antigen and causes nonstimulated lymphocytes to undergo blast transformation and cell division; called also blastogenic factor.macrophage-activating factor (MAF) interferon-α.macrophage colony-stimulating factor (M-CSF) a factor" >colony-stimulating factor secreted by macrophages, stimulated endothelial cells, and most tissues, that stimulates the production of macrophages from precursor cells and maintains the viability of mature macrophages in vitro.macrophage chemotactic factor (MCF) a lymphokine that attracts macrophages to the invasion site.macrophage-derived growth factor a substance released by macrophages below the surface of a wound that induces the proliferation of fibroblasts.macrophage inhibition factor (macrophage inhibitory factor) migration inhibitory factor.migration inhibition factor (migration inhibitory factor) a lymphokine that inhibits macrophage migration.minification factor in radiology, the gain in light achieved by a reduction in size of the output phosphor from the input phosphor size.osteoclast-activating factor (OAF) a lymphokine that stimulates bone resorption; it may be involved in the bone resorption associated with multiple myeloma and other hematologic neoplasms or inflammatory disorders such as rheumatoid arthritis and periodontal disease.factor P properdin.platelet f's see platelet factors.platelet-activating factor (PAF) a substance released by basophils and mast cells in hypersensitivity" >immediate hypersensitivity reactions, and by macrophages and neutrophils in other inflammatory reactions; it leads to bronchoconstriction, platelet aggregation, and release of vasoactive substances from platelets.platelet-derived growth factor a substance contained in platelets and capable of inducing proliferation of vascular endothelial cells, vascular smooth muscle cells, fibroblasts, and glial cells; its action contributes to the repair of damaged vascular walls.R factor R plasmid.releasing f's factors elaborated in one structure (as in the hypothalamus) that effect the release of hormones from another structure (as from the anterior pituitary gland), including corticotropin-releasing factor, melanocyte-stimulating hormone–releasing factor, and prolactin-releasing factor. Applied to substances of unknown chemical structure, while substances of established chemical identity are called releasing hormones.resistance factor R f.Rh factor a type of agglutinogen found on some erythrocytes; see also rh factor" >rh factor.rheumatoid factor (RF) antibodies directed against antigenic determinants on IgG molecules, found in the serum of about 80 per cent of patients with classic or definite rheumatoid arthritis; but in only about 20 per cent of patients with juvenile rheumatoid arthritis; rheumatoid factors may be IgM, IgG, or IgA antibodies, although serologic tests measure only IgM. Rheumatoid factors also occur in other connective tissue diseases and infectious diseases.risk factor an agent or situation that is known to make an individual or population more susceptible to the development of a specific negative condition.risk factor (omaha) an environmental, psychosocial, or physiologic event or health related behavior that increases the client's exposure or vulnerability to the development of a client problem; the nurse's knowledge base of risk factors is used to identify potential modifiers" >problem modifiers in the scheme" >Problem Classification scheme of the omaha system." >omaha system.stable factor factor VII, one of the coagulation factors.Stuart factor (Stuart-Prower factor) factor X, one of the coagulation factors.sun protection factor (SPF) a numerical rating of the amount of protection afforded by a sunscreen; the higher the number, the more protection is provided.tissue factor factor III, one of the coagulation factors.transfer factor (TF) a factor occurring in sensitized lymphocytes that can transfer delayed hypersensitivity to a formerly nonreactive individual; see also transfer factor.tumor necrosis factor (TNF) either of two lymphokines produced primarily by cells of the immune system, capable of causing in vivo hemorrhagic necrosis of certain tumor cells but not normal cells. They also destroy cells associated with the response" >inflammatory response. They have been used as experimental anticancer agents but can also induce shock when bacterial endotoxins cause their release. Tumor necrosis factor α, formerly called cachectin, contains 157 amino acids and is produced by macrophages, eosinophils, and NK cells. Tumor necrosis factor β is lymphotoxin and contains 171 amino acids.vascular endothelial growth factor (VEGF) (vascular permeability factor (VPF)) a peptide factor that stimulates the proliferation of cells of the endothelium of blood vessels; it promotes tissue vascularization and is important in blood vessel formation in tumors. von Willebrand's factor (vWF) a glycoprotein synthesized in endothelial cells and megakaryocytes that circulates complexed to coagulation factor VIII. It is involved in adhesion of platelets to damaged epithelial surfaces and may participate in platelet aggregation. Deficiency results in the prolonged bleeding time seen in von Willebrand's disease.

antihemophilic factor (AHF, factor VIII)

Advate, Alphanate, Hemofil M, Koate-DVI, Kogenate FS, Monarc-M, Monoclate-P, Recombinate, ReFacto

Pharmacologic class: Hemostatic

Therapeutic class: Antihemophilic

Pregnancy risk category C

FDA Box Warning

• Drug is made from human plasma and may contain infectious agents. Plasma donor screening, testing, and inactivation or removal methods reduce this risk.

Action

Promotes conversion of prothrombin to thrombin (necessary for hemostasis and blood clotting). Also replaces missing or deficient clotting factors, thereby controlling or preventing bleeding.

Availability

I.V. injection: 250, 500, 1,000, or 1,500 international units/vial in numerous preparations

Indications and dosages

➣ Spontaneous hemorrhage in patients with hemophilia A (factor VIII deficiency)

Adults and children: Dosage is highly individualized, calculated as follows: AHF required (international units) equals weight (kg) multiplied by desired factor VIII increase (% of normal) multiplied by 0.5.

To control bleeding, desired factor VIII level is 20% to 40% of normal for minor hemorrhage; 30% to 60% of normal for moderate hemorrhage; or 60% to 100% of normal for severe hemorrhage. To prevent spontaneous hemorrhage, desired factor VIII level is 5% of normal.

Contraindications

• Hypersensitivity to drug or to mouse, hamster, or bovine protein

Precautions

Use cautiously in:

• hepatic disease

• blood types A, B, and AB

• patients receiving factor VIII inhibitors

• pregnant patients

• neonates and infants.

Administration

• Before giving, verify that patient has no history of hypersensitivity to drug or to mouse, hamster, or bovine protein.

• Follow prescriber's instructions regarding hepatitis B prophylaxis before starting therapy.

• Refrigerate concentrate until ready to reconstitute drug; then warm to room temperature before mixing.

• Roll bottle gently between hands until drug is well-mixed.

• Give a single dose over 5 to 10 minutes at rate of 2 to 10 ml/minute, as appropriate.

• After drug is reconstituted, don't refrigerate, shake, or store near heat.

• Don't mix with other I.V. solutions.

• Use plastic (not glass) syringe and filter.

Adverse reactions

CNS: headache; lethargy; fatigue; dizziness; jitteriness; drowsiness; depersonalization; tingling in arms, ears, and face

CV: chest tightness, angina pectoris, tachycardia, slight hypotension, thrombosis

EENT: blurred or abnormal vision, eye disorder, otitis media, epistaxis, rhinitis, sore throat

GI: nausea, vomiting, diarrhea, constipation, stomachache, abdominal pain, gastroenteritis, anorexia,

Hematologic: forehead bruises, increased bleeding tendency, thrombocytopenia, hemolytic anemia, intravascular hemolysis, hyperfibrinogenemia

Hepatic: hepatitis B transmission Musculoskeletal: myalgia, muscle weakness, bone pain, finger pain

Respiratory: dyspnea, coughing, wheezing, bronchospasm

Skin: rash, acne, flushing, diaphoresis, urticaria

Other: taste changes, allergic reaction, fever, chills, cold feet, cold sensations, infected hematoma, stinging at injection site, anaphylaxis, human immunodeficiency virus transmission

Interactions

Drug-diagnostic tests. Bilirubin, creatine kinase: increased levels

Hemoglobin, platelets: decreased values

Patient monitoring

See Monitor for signs and symptoms of anaphylaxis and hemolysis.

See Watch for bleeding tendency and hemorrhaging.

• Check vital signs regularly.

• Monitor CBC and coagulation studies.

See Assess for severe headache (may indicate intracranial hemorrhage).

Patient teaching

See Tell patient to immediately report signs and symptoms of allergic response or bleeding tendency.

• Caution patient not to use aspirin during therapy.

• Instruct patient to contact prescriber if drug becomes less effective.

• Tell patient to report signs or symptoms of hepatitis B.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration, alertness, and vision.

• Advise patient to minimize GI upset by eating small, frequent servings of food and drinking plenty of fluids.

• Notify patient that he'll undergo regular blood testing during therapy.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the tests mentioned above.

fac·tor VIII

in the clotting of blood, also known as: antihemophilic factor A (Brinkhous), antihemophilic globulin (1) (Patek and Taylor), antihemophilic globulin A (Cramer), plasma thromboplastin factor (Ratnoff), plasma thromboplastin factor A (Aggeler), thromboplastic plasma component (Shinowara), thromboplastinogen (Quick), prothrombokinase (Feissly), platelet cofactor (Johnson), plasmokinin (Laki), thrombokatilysin (Leggenhager), and proserum prothrombin conversion accelerator. Factor VIII participates in the clotting of the blood by forming a complex with factor IXa, platelets, and calcium and by enzymatically catalyzing the activation of factor X. Deficiency of factor VIII is associated with classic hemophilia A. Factor VIIIC is the coagulant component of factor VIII which, in normal people, circulates in the plasma complexed with Factor VIIIR (von Willebrand factor), the plasma factor VIII-related protein, a large glycoprotein component that is synthesized by endothelial cells and megakaryocytes, and circulates in the plasma where it binds to arteries that have lost their endothelial cell linings, creating a surface to which platelets adhere. Disorders involving factor VIIIR comprise a heterogenous group of abnormalities called von Willebrand disease. A deficiency of factor VIII can lead to impaired blood coagulation. Synonym(s): antihemophilic factor A, antihemophilic globulin A, antihemophilic globulin (1) , plasma thromboplastin factor, platelet cofactor I, prothrombokinase

factor VIII

n. A protein substance in blood plasma that is an essential part of the blood-clotting process. Most cases of hemophilia are caused by a genetic defect that leads to a deficiency of this factor. Also called antihemophilic factor.

factor VIII

(1) The attribute of von Willebrand factor (vWF) required for platelet agglutination by ristocetin; there is no specific equivalent term, as the use of specific terminology for functional activities of vWF is not recommended by the Nomenclature Committee.
(2) Factor VIIIc—the functional attribute of factor VIII that is absent in factor-VIII deficiency (haemophilia A) and measured by standard coagulation techniques.
(3) Factor VIII (in current use)—the protein that is defective or absent in factor-VIII deficiency (haemophilia A).

factor VIII

Anti-hemophilic factor Hematology A heterotrimeric coagulation factor that forms a complex with factor IX, platelets, and calcium, thereby activating factor X; factor VIII is present in cryoprecipitated plasma, and is also used to treat hemophilia A; recombinant factor VIII–rF VIII therapy is used for hemophilia A

fac·tor VIII

(fak'tŏr) A plasma factor in blood coagulation; participates in the clotting of the blood by forming a complex with factor IXa, platelets, and calcium and enzymatically catalyzing the activation of factor X; deficiency is associated with classic hemophilia A. Factor VIII:C is the coagulant component of factor VIII, which circulates in the plasma complexed with factor VIIIR (von Willebrand factor), a glycoprotein that is synthesized by endothelial cells and megakaryocytes, and binds to arteries that have lost their endothelial cell linings, creating a surface to which platelets adhere. Disorders involving factor VIIIR form a heterogenous group of abnormalities called von Willebrand disease.
Synonym(s): antihemophilic factor A, antihemophilic globulin A, proserum prothrombin conversion accelerator.

factor VIII

A protein (globulin) necessary for the proper clotting of the blood. The absence of Factor VIII causes HAEMOPHILIA but it can be isolated from donated blood and given to haemophiliacs to control their bleeding tendency. The drug is on the WHO official list.

Factor VIII

A protein involved in blood clotting that requires vWF for stability and long-term survival in the bloodstream.Mentioned in: Von Willebrand Disease

fac·tor VIII

(fak'tŏr) In blood clotting, it participates in the clotting of the blood by forming a complex with factor IXa, platelets, and calcium and by enzymatically catalyzing the activation of factor X.

factor VIII

factor VIII

factor VIII

factor VIII

factor VIII

factor VIII

factor VIII

factor

antihemophilic factor (AHF, factor VIII)

FDA Box Warning

Action

Availability

Indications and dosages

Contraindications

Precautions

Administration

Adverse reactions

Interactions

Patient monitoring

Patient teaching

fac·tor VIII

factor VIII

factor VIII

factor VIII

fac·tor VIII

factor VIII

Factor VIII

fac·tor VIII

factor VIII

Synonyms for factor VIII

noun a coagulation factor (trade name Hemofil) whose absence is associated with hemophilia A

Synonyms

Related Words