factor VIII inhibitor

factor VIII inhibitor

IgG alloantibodies to factor VIIIc that inhibits coagulation, which occur in up to 50% of Pts with severe hemophilia A; factor VIII antibodies may arise spontaneously in inflammatory diseases–eg, SLE, rheumatoid arthritis, and ulcerative colitis, or with ↑ age, during post-partum period, or in drug reactions Mechanism Factor VIII inhibitor inactivates factor VIII by steric prevention of interaction of factor VIII with vWF, phospholipids, activated factors IX and X, and thombin, and by proteolysis. See Bethesda units, Factor VIII.