acquired megacolon

megacolon

[meg″ah-ko´lon] dilatation and hypertrophy of the colon.

Megacolon. From McKinney et al., 2000acquired megacolon colonic enlargement associated with chronic constipation, but with normal ganglion cell innervation.acute megacolon toxic megacolon.aganglionic megacolon (congenital megacolon) Hirschsprung's disease.toxic megacolon acute dilatation of the colon associated with amebic dysentery" >amebic dysentery or ulcerative colitis" >ulcerative colitis; called also acute megacolon.

ac·quired meg·a·co·lon

megacolon occurring in association with an acquired disease; occurs in inflammatory bowel disease (toxic megacolon) and Chagas disease (South American trypanosomiasis).

megacolon

A massively distended colon with ↓ activity, due to defective innervation–congenital, intraluminal overgrowth of microorganisms or of psychogenic origin Clinical Intestinal obstruction, constipation, vomiting, abdominal distension, poor weight gain, retarded growth Management Temporary colostomy for bowel rest, followed by resection of affected bowel segment Prognosis Sx eliminated in ± 90% of Pts with surgery; outcomes better with early intervention Megacolon Congenital megacolon Congenital aganglionosis, Hirschsprung's disease A disease affecting 1:5000 live births, with a sibling risk of 1% for girls and 5% for boys; Hirschsprung's disease–HD is ten-fold more common in Down syndrome; other anomalies in HD include hydrocephalus, VSD, cryptorchism, diverticulosis of the urinary bladder, renal cysts and agenesis, polyposis coli, Laurence-Moon-Biedl syndrome Treatment Resection of aganglionic colon Acquired megacolon A condition related to narcotics or disruption of ganglionic innervation–eg idiopathic hypomotility, neuropathies–parkinsonism, multiple sclerosis, myotonic dystrophy, diabetic neuropathy, Chagas' disease, smooth muscle disorders–amyloidosis and progressive systemic sclerosis and metabolic disease–hypokalemia, lead poisoning, porphyria, pheochromocytoma, hypothyroidism and may be due to intraluminal overgrowth of microorganisms in Crohn's disease and ulcerative colitis–toxic megacolon–characterized by mucosal necrosis, transmural inflammation and systemic 'toxicity' associated with high fever, tachycardia, leukocytosis and diarrhea; in psychogenic megacolon, no radiologic or pathologic defects are present–the condition may be related to a 'fixation' in Freud's anal retentive stage of psychosexual development, with constipation of later onset than in HD, possibly 2º to abuse of anthracine laxatives

ac·quired meg·a·co·lon

(ă-kwīrd megă-kō-lŏn) Megacolon associated with disease; occurs in inflammatory bowel disease and Chagas disease.

单词	acquired megacolon
释义	DictionarySeemegacolonEncyclopediaSeeMegacolon acquired megacolon megacolon [meg″ah-ko´lon] dilatation and hypertrophy of the colon.Megacolon. From McKinney et al., 2000acquired megacolon colonic enlargement associated with chronic constipation, but with normal ganglion cell innervation.acute megacolon toxic megacolon.aganglionic megacolon (congenital megacolon) Hirschsprung's disease.toxic megacolon acute dilatation of the colon associated with amebic dysentery" >amebic dysentery or ulcerative colitis" >ulcerative colitis; called also acute megacolon. ac·quired meg·a·co·lon megacolon occurring in association with an acquired disease; occurs in inflammatory bowel disease (toxic megacolon) and Chagas disease (South American trypanosomiasis). megacolon A massively distended colon with ↓ activity, due to defective innervation–congenital, intraluminal overgrowth of microorganisms or of psychogenic origin Clinical Intestinal obstruction, constipation, vomiting, abdominal distension, poor weight gain, retarded growth Management Temporary colostomy for bowel rest, followed by resection of affected bowel segment Prognosis Sx eliminated in ± 90% of Pts with surgery; outcomes better with early intervention Megacolon Congenital megacolon Congenital aganglionosis, Hirschsprung's disease A disease affecting 1:5000 live births, with a sibling risk of 1% for girls and 5% for boys; Hirschsprung's disease–HD is ten-fold more common in Down syndrome; other anomalies in HD include hydrocephalus, VSD, cryptorchism, diverticulosis of the urinary bladder, renal cysts and agenesis, polyposis coli, Laurence-Moon-Biedl syndrome Treatment Resection of aganglionic colon Acquired megacolon A condition related to narcotics or disruption of ganglionic innervation–eg idiopathic hypomotility, neuropathies–parkinsonism, multiple sclerosis, myotonic dystrophy, diabetic neuropathy, Chagas' disease, smooth muscle disorders–amyloidosis and progressive systemic sclerosis and metabolic disease–hypokalemia, lead poisoning, porphyria, pheochromocytoma, hypothyroidism and may be due to intraluminal overgrowth of microorganisms in Crohn's disease and ulcerative colitis–toxic megacolon–characterized by mucosal necrosis, transmural inflammation and systemic 'toxicity' associated with high fever, tachycardia, leukocytosis and diarrhea; in psychogenic megacolon, no radiologic or pathologic defects are present–the condition may be related to a 'fixation' in Freud's anal retentive stage of psychosexual development, with constipation of later onset than in HD, possibly 2º to abuse of anthracine laxatives ac·quired meg·a·co·lon (ă-kwīrd megă-kō-lŏn) Megacolon associated with disease; occurs in inflammatory bowel disease and Chagas disease.
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