aminoglycoside

enUK

aminoglycoside

[ah-me″no-gli´ko-sīd] any of a group of antibacterial antibiotics derived from species of Streptomyces; they interfere with the function of bacterial ribosomes. They contain an inositol moiety substituted with two amino or guanidino groups and with one or more sugars or aminosugars. The group includes amikacin, gentamicin, kanamycin, neomycin, streptomycin, and tobramycin. They are used to treat infections caused by gram-negative organisms and are classified as bactericidal agents because of their interference with bacterial replication. All are highly toxic, requiring frequent monitoring of blood serum levels and careful observation of the patient for early signs of toxicity, particularly ototoxicity and nephrotoxicity.

a·mi·no·gly·co·side

(ă-mē'nō-glī'kō-sīd), Any one of a group of bacteriocidal antibiotics derived from species of Streptomyces or Micromonosporum and characterized by two or more amino sugars joined by a glycoside linkage to a central hexose; aminoglycosides act by causing misreading and inhibition of protein synthesis on bacterial ribosomes and are effective against aerobic gram-negative bacilli and Mycobacterium tuberculosis. Some commonly used aminoglycosides are streptomycin, neomycin, and gentamicin.

aminoglycoside

(ə-mē′nō-glī′kə-sīd′, ăm′ə-)n. Any of a group of broad-spectrum antibiotics, such as streptomycin, derived from species of Streptomyces or Micromonospora bacteria and used to treat infections caused by gram-negative bacteria.

aminoglycoside

Any of a family of broad-spectrum antibiotics (amikacin, gentamicin, kanamycin, netilmicin, neomycin, framycetin, streptomycin, tobramycin) which are used primarily against aerobic gram-negative bacteria.

Pharmacodynamics
Poorly absorbed per os; poor penetration of CNS-BBB; rapid excretion if kidneys are normal.

Types
Gentamicin, streptomycin, tobramycin.

Toxicity
Dose-related (kidneys, vestibular, auditory and neuromuscular systems), minor skin rash, drug fever, decreased Mg2+, decreased Ca2+, decreased K+; it is common practice to monitor patients receiving AGs.

aminoglycoside

Therapeutics Any of a family of broad-spectrum antibiotics–amikacin, gentamicin, kanamycin, netilmicin, neomycin, framycetin, streptomycin, tobramycin, which are used primarily against aerobic gram-negative bacteria Pharmacodynamics Poorly absorbed per os, poor penetration of CNS–BBB, rapid excretion if kidneys are normal Types Gentamicin, streptomycin, tobramycin Toxicity Dose-related–kidneys, vestibular, auditory, and neuromuscular systems, minor skin rash, drug fever, ↓ Mg2+, ↓ Ca2+, ↓ K+; it is common practice to monitor Pts receiving AGs. See Therapeutic drug monitoring.

aminoglycoside

Any one of a group of antibiotics composed of amino sugars in glycoside linkage which act by interfering with the synthesis of bacterial proteins. It is used in the treatment of infections caused by Gram-negative bacteria. Examples: framycetin, gentamicin, neomycin and tobramycin.

a·mi·no·gly·co·side

(ă-mē'nō-glī'kō-sīd) Any bacteriocidal antibiotic derived from species of Streptomyces or Micromonosporum; effective against aerobic gram-negative bacilli and Mycobacterium tuberculosis.

单词	aminoglycoside
释义	aminoglycoside enUK a·mi·no·gly·co·side A0256250 (ə-mē′nō-glī′kə-sīd′, ăm′ə-)n. Any of a group of broad-spectrum antibiotics, such as streptomycin, derived from species of Streptomyces or Micromonospora bacteria and used to treat infections caused by gram-negative bacteria. aminoglycoside enUK aminoglycoside [ah-me″no-gli´ko-sīd] any of a group of antibacterial antibiotics derived from species of Streptomyces; they interfere with the function of bacterial ribosomes. They contain an inositol moiety substituted with two amino or guanidino groups and with one or more sugars or aminosugars. The group includes amikacin, gentamicin, kanamycin, neomycin, streptomycin, and tobramycin. They are used to treat infections caused by gram-negative organisms and are classified as bactericidal agents because of their interference with bacterial replication. All are highly toxic, requiring frequent monitoring of blood serum levels and careful observation of the patient for early signs of toxicity, particularly ototoxicity and nephrotoxicity. a·mi·no·gly·co·side (ă-mē'nō-glī'kō-sīd), Any one of a group of bacteriocidal antibiotics derived from species of Streptomyces or Micromonosporum and characterized by two or more amino sugars joined by a glycoside linkage to a central hexose; aminoglycosides act by causing misreading and inhibition of protein synthesis on bacterial ribosomes and are effective against aerobic gram-negative bacilli and Mycobacterium tuberculosis. Some commonly used aminoglycosides are streptomycin, neomycin, and gentamicin. aminoglycoside (ə-mē′nō-glī′kə-sīd′, ăm′ə-)n. Any of a group of broad-spectrum antibiotics, such as streptomycin, derived from species of Streptomyces or Micromonospora bacteria and used to treat infections caused by gram-negative bacteria. aminoglycoside Any of a family of broad-spectrum antibiotics (amikacin, gentamicin, kanamycin, netilmicin, neomycin, framycetin, streptomycin, tobramycin) which are used primarily against aerobic gram-negative bacteria. Pharmacodynamics Poorly absorbed per os; poor penetration of CNS-BBB; rapid excretion if kidneys are normal. Types Gentamicin, streptomycin, tobramycin. Toxicity Dose-related (kidneys, vestibular, auditory and neuromuscular systems), minor skin rash, drug fever, decreased Mg2+, decreased Ca2+, decreased K+; it is common practice to monitor patients receiving AGs. aminoglycoside Therapeutics Any of a family of broad-spectrum antibiotics–amikacin, gentamicin, kanamycin, netilmicin, neomycin, framycetin, streptomycin, tobramycin, which are used primarily against aerobic gram-negative bacteria Pharmacodynamics Poorly absorbed per os, poor penetration of CNS–BBB, rapid excretion if kidneys are normal Types Gentamicin, streptomycin, tobramycin Toxicity Dose-related–kidneys, vestibular, auditory, and neuromuscular systems, minor skin rash, drug fever, ↓ Mg2+, ↓ Ca2+, ↓ K+; it is common practice to monitor Pts receiving AGs. See Therapeutic drug monitoring. aminoglycoside Any one of a group of antibiotics composed of amino sugars in glycoside linkage which act by interfering with the synthesis of bacterial proteins. It is used in the treatment of infections caused by Gram-negative bacteria. Examples: framycetin, gentamicin, neomycin and tobramycin. a·mi·no·gly·co·side (ă-mē'nō-glī'kō-sīd) Any bacteriocidal antibiotic derived from species of Streptomyces or Micromonosporum; effective against aerobic gram-negative bacilli and Mycobacterium tuberculosis.
随便看	mount john university observatory mount joy mount joy mennonite church mount juliet christian academy mount juliet high school mount juliet-wilson county library mount ka'ala mount kaala mount kailash mount kailas/lake manasarovar mount kanchenjunga mount karisimbi mount kaufmann mount kazbek mount kenia mount kenya mount kenya safari club mount kenya university mount kenya wildlife conservancy mount kerketeos mount kerketeus mount kerkis mount kilamanjaro mount kilimanjaro mount kiliminjaro