chronic neutrophilic leukaemia

A rare myeloproliferative disorder characterised by prominent neutrophilia in peripheral blood, myeloid hyperplasia in the bone marrow, hepatosplenomegaly and an absence of the Philadelphia chromosome or BCR/ABL fusion gene.
Clinical findings
Hepatosplenomegaly; less commonly: pruritus, gout, mucocutaneous bleeding.
DiffDx
CML, neutrophilic-CML, myelodysplastic syndrome.
Management
Hydroxyurea to control leukocytosis and reduce splenomegaly; chemotherapy.
Prognosis
Uncertain; patients die in blast transformation or with progressive leucocytosis.

单词	chronic neutrophilic leukaemia
释义	chronic neutrophilic leukaemia chronic neutrophilic leukaemia A rare myeloproliferative disorder characterised by prominent neutrophilia in peripheral blood, myeloid hyperplasia in the bone marrow, hepatosplenomegaly and an absence of the Philadelphia chromosome or BCR/ABL fusion gene. Clinical findings Hepatosplenomegaly; less commonly: pruritus, gout, mucocutaneous bleeding. DiffDx CML, neutrophilic-CML, myelodysplastic syndrome. Management Hydroxyurea to control leukocytosis and reduce splenomegaly; chemotherapy. Prognosis Uncertain; patients die in blast transformation or with progressive leucocytosis.
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