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Eaton-Lambert syndrome
Thesaurus| Noun | 1. | Eaton-Lambert syndrome - a disease seen in patients with lung cancer and characterized by weakness and fatigue of hip and thigh muscles and an aching back; caused by antibodies directed against the neuromuscular junctionscarcinomatous myopathy, Lambert-Eaton syndrome, myasthenic syndromedisease of the neuromuscular junction - a disease characterized by impairment of neuromuscular junctions |
EncyclopediaSeesyndromeEaton-Lambert syndrome
Eaton-Lambert syndrome [e´ton lam´bert] a myasthenia-like syndrome in which the weakness usually affects the limbs but ocular and bulbar muscles are spared; often associated with oat-cell carcinoma of the lung.Lam·bert-Ea·ton myasthenic syn·drome (LEMS), (lam'bert ē'tŏn), a generalized disorder of neuromuscular transmission caused by a defect in the release of acetylcholine quanta from the presynaptic nerve terminals; often associated with small cell carcinoma of the lung, particularly in elderly men with a long history of cigarette smoking. In contrast to myasthenia gravis, weakness tends to affect solely axial muscles, girdle muscles, and less often the limb muscles; autonomic disturbances, for example, dry mouth and impotence, are common; the deep tendon reflexes are unelicitable; on motor conduction studies, responses on initial stimulation are quite low in amplitude, but they show marked posttetanic facilitation after a few seconds of exercise. Lambert-Eaton syndrome is due to loss of voltage-sensitive calcium channels located on the presynaptic motor nerve terminal. See: myasthenic syndrome. Synonym(s): carcinomatous myopathy, Eaton-Lambert syndrome, Lambert syndrome, Lambert-Eaton syndrome, myasthenic syndromeEaton, Lee M., U.S. neurologist, 1905-1958. Eaton-Lambert syndrome - Synonym(s): Lambert-Eaton syndromeLambert-Eaton syndrome - see under Lambert, Edward H
Lambert, Edward H., U.S. neurophysiologist, 1915–. Eaton-Lambert syndrome - Synonym(s): Lambert-Eaton syndromeLambert-Eaton syndrome - progressive proximal muscle weakness in patients with carcinoma, caused by antibodies directed against motor-nerve axon terminals. Synonym(s): Eaton-Lambert syndromeEaton-Lambert syndrome
Related to Eaton-Lambert syndrome: LemsSynonyms for Eaton-Lambert syndromenoun a disease seen in patients with lung cancer and characterized by weakness and fatigue of hip and thigh muscles and an aching backSynonyms- carcinomatous myopathy
- Lambert-Eaton syndrome
- myasthenic syndrome
Related Words- disease of the neuromuscular junction
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