单词 | chronotherapy |
释义 | chronotherapychron·o·ther·a·pyC0341675 (krŏn′ō-thĕr′ə-pē, krō′nə-)chronotherapy(ˌkrɒnəˈθɛrəpɪ)chronotherapychronotherapy[¦krä·nō′ther·ə·pē]chronotherapychro·no·ther·ap·y(kron'ō-thār'ă-pē),See also: chronooncology. chronotherapy(krŏn′ō-thĕr′ə-pē, krō′nə-)chronotherapyAny therapy based on the timing of physiologic and pathologic events.Alternative medicine The process in which a person’s daily activities are supposedly synchronised with a natural metabolic rhythm in a 24-hour cycle. Chronotherapy establishes routines of exercise, eating, work, study, rest and sleep. Oncology The adminstration of chemotherapy doses synchronised to the body’s circadian rhythm. Chronotherapy may increase allowable doses of chemotherapeutics, while decreasing tumour burden and chemotherapy-related side effects. Chronotherapeutics, core concepts ▪ Predictable pattern—Bioperiodic variation in manifestations of disease that are common to all individuals. ▪ Individual pattern—Variations in chronokinetics unique to one person. Chronotherapeutics, relevance ▪ Variation in intensity of symptoms over time—e.g., allergic rhinitis, angina, asthma, MI, postsurgical pain, ulcer disease. ▪ Where therapeutic-to-toxic ratio varies predictably—e.g., chemotherapy. ▪ Where pharmacokinetics are known to be biologic rhythm-dependent—e.g., antihistamines, antihypertensives, heparin, NSAIDs. ▪ Where hormonal manipulation is intended to simulate the normal temporal ebb-and-flow hormone levels—e.g., insulin in IDDM, corticosteroid and luteinising hormone-releasing hormone. chronotherapyAny therapy based on the timing of physiologic and pathologic event. See Bright light therapy, Chronobiology, Circadian rhythm, Seasonal affective disorder Oncology The adminstration of chemotherapy doses synchronized to the body's circadian rhythm; CT may ↑ allowable doses of chemotherapeutics, ↓ tumor burden, and chemotherapy-related side effects. |
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