bottom-up model

One of two proposed mechanisms of spontaneous gastrointestinal tract adenomas. In the bottom up model, a stem cell situated in the base of a crypt acquires mutations in the adenomatous polyposis coli (APC) tumour-suppressor gene, impairing the function of the APC protein. The bottom-up theory holds that adenomas, both familial/hereditary and sporadic, arise from a monoclonal proliferation in the gland crypts (monocryptal adenoma), followed by the multistep process of carcinogenesis.

单词	bottom-up model
释义	bottom-up model bottom-up model (programming)A method for estimating the cost of a completesoftware project by combining estimates for each component. bottom-up model bottom-up model One of two proposed mechanisms of spontaneous gastrointestinal tract adenomas. In the bottom up model, a stem cell situated in the base of a crypt acquires mutations in the adenomatous polyposis coli (APC) tumour-suppressor gene, impairing the function of the APC protein. The bottom-up theory holds that adenomas, both familial/hereditary and sporadic, arise from a monoclonal proliferation in the gland crypts (monocryptal adenoma), followed by the multistep process of carcinogenesis.
随便看	break up with us break up with you break us break us down break us of break us up breakwall break water breakwater breakwaters breakwater structures break wind break with break with her break with him break with it break with me break with one break with someone break with (something or someone) break with them break with tradition break with us break with you break word