complement cascade

Immunology A complex, multimolecular biologic system with ± 25 different proteins that self-assemble on cell surfaces, functioning in concert with the specific immune systems to mediate host reactions and anti-microbial defense; the coup de grâce for the hapless target cell is the polymerization of C9 on its surface, which forms a transmembrane 'doughnut' that facilitates the egress of ions, cell lysis and death. See Complement. Cf Alternate pathway, Classic pathway, Common pathway.

单词	complement cascade
释义	DictionarySeecomplement complement cascade complement cascade [′käm·plə·mənt kas′kād] (immunology) The sequential activation of complement proteins resulting in lysis of a target cell. complement cascade complement cascade Immunology A complex, multimolecular biologic system with ± 25 different proteins that self-assemble on cell surfaces, functioning in concert with the specific immune systems to mediate host reactions and anti-microbial defense; the coup de grâce for the hapless target cell is the polymerization of C9 on its surface, which forms a transmembrane 'doughnut' that facilitates the egress of ions, cell lysis and death. See Complement. Cf Alternate pathway, Classic pathway, Common pathway.
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