anaemia of chronic disease

A form of anaemia that accounts for 1/4 of all anaemias in hospitalised patients; it is the predominant form of hypoproliferative anaemia, which interferes with RBC production and shortens RBC lifespan, and is seen in patients with arthritis, chronic infections, and malignancy.

Clinical findings
The findings in anaemia of chronic disease reflect the underlying aetiology.
Lab
Mild-to-moderate anaemia, often microcytic ± hypochromic; iron stores may be low/normal; RBC indices may be normal.

Pathogenesis
Unknown; possibly related to IFN-gamma produced by activated macrophages.

Management
Transfusion, erythropoietin.

单词	anaemia of chronic disease
释义	anaemia of chronic disease anaemia of chronic disease A form of anaemia that accounts for 1/4 of all anaemias in hospitalised patients; it is the predominant form of hypoproliferative anaemia, which interferes with RBC production and shortens RBC lifespan, and is seen in patients with arthritis, chronic infections, and malignancy. Clinical findings The findings in anaemia of chronic disease reflect the underlying aetiology. Lab Mild-to-moderate anaemia, often microcytic ± hypochromic; iron stores may be low/normal; RBC indices may be normal. Pathogenesis Unknown; possibly related to IFN-gamma produced by activated macrophages. Management Transfusion, erythropoietin.
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