caspase 9


caspase 9

A member of the CED-3 subfamily caspase-type protease activated by Apaf-1 binding, which is responsible for the proteolytic cleavage of many key proteins in apoptosis; caspase-9 plays a central role in cell death through an array of apoptosis inducers—e.g., TNF-alpha, TRAIL, anti-CD-95, FADD, TRADD4.