c-Rel


c-Rel

A member of the NF-kappaB family of transcription factors encoded by REL on chromosome 2p13-p12, which is distinguished by the presence of an N-terminal Rel homology domain.
Significance
c-Rel overexpression causes downregulation of EPHB2 (an ephrin receptor tyrosine kinase in the intestine), and is associated with a poor prognosis in colorectal carcinoma.