单词 | actinomycin d |
释义 | actinomycin Dactinomycin Dactinomycin Ddac·ti·no·my·cin(dak'ti-nō-mī'sin),See also: actinomycins. actinomycin DActinomycin DA relatively toxic antibiotic produced by Streptomyces spp, which is used as a chemotherapeutic.Mechanism Inhibits DNA transcription by RNA polymerase. Indications Rhabdomyosarcoma, Wilms’ tumour, gestational trophoblastic tumour Adverse effects Anorexia, nausea, vomiting, myelosuppression with pancytopenia, diarrhoea actinomycin DCosmegen®, dactinomycin Oncology A relatively toxic antibiotic produced by Streptomyces spp, used as a chemotherapeutic Mechanism Inhibits DNA transcription by RNA polymerase Indications Rhabdomyosarcoma, Wilms' tumor Adverse effects Anorexia, N&V, myelosuppression with pancytopenia, diarrheaactinomycin DDactinomycin, an antibiotic derived from Streptomyces pavullus which causes breaks in DNA. This side effect renders it unsuitable as an antibacterial drug, but makes it useful as an anti-cancer drug. A brand name is Cosmegen Lyovac. There are other actinomycins in the group produced by Streptomyces chrysomallas .actinomycin Da substance that inhibits the transcription of RNA from DNA. When isolated from soil bacteria and used pharmaceutically it acts as an ANTIBIOTIC. |
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