CD25

a type I transmembrane protein present on activated T cells, activated B cells, some thymocytes, myeloid precursors, and oligodendrocytes that associates with CD122 to form a heterodimer that can act as a high-affinity receptor for IL-2; expressed in most B-cell neoplasms, some acute nonlymphocytic leukemias, and neuroblastomas.

CD25

A 55-kD monomeric glycoprotein low-affinity receptor for IL-2–IL-2R alpha. With p75 beta chain—CD122 antigen, IL-2Rbeta—CD25 forms a high affinity IL-2R complex.
Normal expression
CD25 is expressed on activated T and B cells in the germinal centre, mantle zone, on activated macrophages and thymic medulla cells; it is absent from thymocytes and resting T and B cells.
Abnormal expression
Hairy cell leukaemia and Hodgkin lymphoma, and may be expressed on T and B cell NHLs, and HTLV I/II-associated T cell leukaemias.

单词	cd25
释义	CD25 CD25 a type I transmembrane protein present on activated T cells, activated B cells, some thymocytes, myeloid precursors, and oligodendrocytes that associates with CD122 to form a heterodimer that can act as a high-affinity receptor for IL-2; expressed in most B-cell neoplasms, some acute nonlymphocytic leukemias, and neuroblastomas. CD25 A 55-kD monomeric glycoprotein low-affinity receptor for IL-2–IL-2R alpha. With p75 beta chain—CD122 antigen, IL-2Rbeta—CD25 forms a high affinity IL-2R complex. Normal expression CD25 is expressed on activated T and B cells in the germinal centre, mantle zone, on activated macrophages and thymic medulla cells; it is absent from thymocytes and resting T and B cells. Abnormal expression Hairy cell leukaemia and Hodgkin lymphoma, and may be expressed on T and B cell NHLs, and HTLV I/II-associated T cell leukaemias.
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