| 释义 |
CD4
CD4 C0181050 (sē′dē-fôr′)n. A glycoprotein that is found on the surface of T cells, especially helper T cells, and functions as a receptor in activation of the cells. In humans, HIV gains entry to helper T cells by binding to the CD4 receptor.
[c(luster of) d(ifferentiation antigen) 4.]CD4
n. a protein on the surface of T cells and other cells, functioning as a receptor for the AIDS virus antigen. [1980–85; c(luster of) d(ifferentiation) 4] Thesaurus| Noun | 1. | CD4 - a glycoprotein that is found primarily on the surface of helper T cells; "CD4 is a receptor for HIV in humans"cluster of differentiation 4glycoprotein - a conjugated protein having a carbohydrate component |
CD4
CD4 (immunology) A T-cell signaling and/or co-stimulatory monomeric transmembrane glycoprotein involved in major histocompatibility complex II adhesion. CD4
CD4 designation for an antigen found on helper T cells; see under antigen.CD4a type I transmembrane protein found on helper/inducer T cells, monocytes, macrophages, and dendritic cells that is involved in T-cell recognition of antigens; expressed in mycosis fungoides, Sézary syndrome, and T-cell lymphomas.CD4 (sē′dē-fôr′)n. A glycoprotein predominantly found on the surface of helper T cells. In humans, it is a receptor for HIV, enabling the virus to gain entry into its host.CD4 A transmembrane glycoprotein present on T helper/inducer cells, which participates in adherence of T cells to target cells, and is involved in thymic maturation and transmission of intracellular signals during T cell activation by the class II MHC; CD4 has inducer or helper activity for T cell, B cell, and macrophage interactions, and evokes T cell proliferation in response to soluble antigens or autologous non-T cells, providing appropriate signals for B cell proliferation and differentiation into Ig-secreting cells; CD4 is also a high-affinity receptor for HIV-1's gp120, binding 42–55 of the NH2 terminal domain amino acids, and has an Ig-like fold similar to the complementarity-determining region of the kappa light chain; CD4 also binds Igs independently of the Fc receptor, and is an accessory to the T-cell receptorCD4A type of protein molecule in human blood that is present on the surface of 65% of human T cells. CD4 is a receptor for the HIV virus. When the HIV virus infects cells with CD4 surface proteins, it depletes the number of T cells, B cells, natural killer cells, and monocytes in the patient's blood. Most of the damage to an AIDS patient's immune system is done by the virus' destruction of CD4+ lymphocytes. CD4 is sometimes called the T4 antigen.Mentioned in: AIDS, AIDS TestsCD4
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| CD4➣Cluster Difference 4 |
CD4
Synonyms for CD4noun a glycoprotein that is found primarily on the surface of helper T cellsSynonyms- cluster of differentiation 4
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