aurora kinase


aurora kinase

an enzyme that plays a role as an essential regulator of cell division. Aurora A and Aurora B kinases are implicated in regulation of spindle assembly and correction of chromosomal segregation.

Aurora kinase

Any of a family of three highly homologous serine/threonine kinases (Aurora kinase A, Aurora kinase B and Aurora kinase C), which play a critical role in regulating many processes that are pivotal to mitosis. Each has a different function in the control of mitosis. They are strongly linked to cancer progression, and while overexpression of Aurora A and B occurs in many cancers, neither is regarded as an oncoprotein (as oncogenic mutations are required to promote tumour progression).