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antimetaboliteenUK
an·ti·me·tab·o·lite A0342650 (ăn′tē-mĭ-tăb′ə-līt′, ăn′tī-)n. A substance that closely resembles an essential metabolite and therefore inhibits physiological reactions involving that metabolite.
an′ti·met′a·bol′ic (-mĕt′ə-bŏl′ĭk) adj.antimetabolite (ˌæntɪmɪˈtæbəˌlaɪt) n (Pharmacology) any drug that acts by disrupting the normal growth of a cell. Sulfonamide drugs are antimetabolites and some antimetabolites are used in cancer treatmentan•ti•me•tab•o•lite (ˌæn ti məˈtæb əˌlaɪt, ˌæn taɪ-)
n. any substance that interferes with growth by competing with a nutrient metabolite for receptors or enzymes in the body, used esp. for treating certain cancers. [1940–45] an`ti•met`a•bol′ic (-ˌmɛt əˈbɒl ɪk) adj. Thesaurus| Noun | 1. | antimetabolite - an antineoplastic drug that inhibits the utilization of a metaboliteantineoplastic, antineoplastic drug, cancer drug - any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiting and hair loss and suppression of bone marrow functionfluorouracil - an antimetabolite used to treat certain cancersmercaptopurine, Purinethol - a drug (trade name Purinethol) that interferes with the metabolism of purine and is used to treat acute lymphocytic leukemiaamethopterin, methotrexate, methotrexate sodium - toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid; used to treat certain cancers and psoriasis and rheumatoid arthritis |
antimetaboliteenUK
antimetabolite: see metabolitemetabolite,
organic compound that is a starting material in, an intermediate in, or an end product of metabolism. Starting materials are substances, usually small and of simple structure, absorbed by the organism as food. These include the vitamins and essential amino acids.
..... Click the link for more information. .antimetabolite[¦an·tē·mə′tab·ə‚līt] (pharmacology) A substance, such as sulfanilamide or amethopterin, that inhibits utilization of an essential metabolite because it is an analog of the metabolite. antimetaboliteenUK
antimetabolite [an″te-, an″ti-mĕ-tab´o-līt] 1. a substance bearing a close structural resemblance to one required for normal physiological functioning, and exerting its effect by interfering with the utilization of the essential metabolite.2. a class of antineoplastic agents consisting of antimetabolites of substances required for cell growth and replication; the interference with cell function is phase specific, largely in the S phase of the cell cycle. The group includes cladribine, cytarabine, floxuridine, fludarabine, fluorouracil, mercaptopurine, methotrexate, and thioguanine. See also antineoplastic therapy.an·ti·me·tab·o·lite (an'tē-me-tab'ō-līt), A substance that competes with, replaces, or antagonizes a particular metabolite; for example, ethionine is an antimetabolite of methionine.antimetabolite (ăn′tē-mĭ-tăb′ə-līt′, ăn′tī-)n. A substance that closely resembles an essential metabolite and therefore inhibits physiological reactions involving that metabolite.
an′ti·met′a·bol′ic (-mĕt′ə-bŏl′ĭk) adj.antimetabolite Antimetabolic agent Pharmacology Any agent–eg, MTX, 6-mercaptopurine, thioguanine, 5-FU, gemcitabine that is a structural analogue of a native cell metabolite, which either inhibits the enzymes of a particular metabolic pathway or is incorporated during synthesis to produce defective product or prevents replication; anti-metabolites are used as chemotherapeutics, antivirals and as immunosuppressants, and include analogues of purines–eg azathioprine, pyrimidines, folic acid–eg aminopterin, MTX See Azathioprine, Methotrexate. an·ti·me·tab·o·lite (an'tē-mĕ-tab'ō-līt) A substance that competes with, replaces, or antagonizes a particular metabolite; e.g., ethionine is an antimetabolite of methionine. antimetabolite An anticancer, or CYTOTOXIC, drug which acts by combining with essential enzymes within cancer cells so as to interfere with their metabolism and growth. To be useful, antimetabolites must be significantly more toxic to cancer cells than to normal cells.AntimetaboliteA drug that interferes with a cell's growth or ability to multiply.Mentioned in: ChemotherapyantimetaboliteenUK
Related to antimetabolite: methotrexateWords related to antimetabolitenoun an antineoplastic drug that inhibits the utilization of a metaboliteRelated Words- antineoplastic
- antineoplastic drug
- cancer drug
- fluorouracil
- mercaptopurine
- Purinethol
- amethopterin
- methotrexate
- methotrexate sodium
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